TWiV 141: Mickey gets HCV

hcv miceHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Matt Evans

Matt Evans joins Vincent, Rich, Dickson, and Alan to deconstruct a mouse model for hepatitis C virus infection.

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Weekly Science Picks

Matt – Benezra letter to NIH (pdf); (NIH response and Nature commentary)
Dickson – The Big Thirst by Charles Fishman
Alan – Earth’s First Steps by Jerry MacDonald
Rich – Final space shuttle launch and NIAID paylines
 Vincent – Hertog Global Strategy Initiative

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TWiV 140: An aptitude for microbicides

cd4 aptamer

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

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Weekly Science Picks

Alan – Inside insides
Rich – Rock stars of science
 Vincent – A new open-access journal, and Francis Collins on NIH budget

Listener Pick of the Week

Kathy – Scientists and musicians compare notes (NPR)

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TWiV 139: Honey, I shrunk the virus

mimivirusHosts: Vincent Racaniello, Alan Dove, and Dickson Despommier

Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.

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Weekly Science Picks

Alan – Life Before the Dinosaurs by ABC
Dickson – Inside Jokes by Matthew M. Hurley
 Vincent – The Tree of Life by Jonathan Eisen

Listener Pick of the Week

Lance – A History of the World since 9/11 by Dominic Streatfeild

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TWiV 138: RISCy business with Raul Andino

Drosophila melanogasterHosts: Vincent Racaniello and Raul Andino

Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.

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TWiV 137: Look what the dog dragged in

dog_humanHosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Amit Kapoor, and Ian Lipkin

The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.

Click the arrow above to play, or right-click to download TWiV #137 (69 MB .mp3, 96 minutes).

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Weekly Science Picks

Alan – What do marine mammals eat? (YouTube)
Rich – NIH rocket boys
Dickson – Cytomegalovirus needs an antiviral protein (Science)
 Vincent – All pdfs free at National Academy of Science Press

Listener Pick of the Week

Adriana and Ye Jung  – The man who was cured of AIDS (article one and two)

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TWiV 136: Exit XMRV

nude mouseHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Stephen Goff

Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.

Click the arrow above to play, or right-click to download TWiV #136 (61 MB .mp3, 84 minutes).

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Weekly Science Picks

Alan – The Demon-Haunted World by Carl Sagan
Rich – Trends in annual rates of death (pdf)
Stephen – Unexpected inheritance (PLoS Pathogens)
 Vincent – Beyond the human eye

Listener Pick of the Week

Raihan  – Bruce Aylward: How we’ll stop polio for good (YouTube)

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TWiV 135: Live in the Big Easy

ASM GM New OrleansHosts: Vincent Racaniello, Roger Hendrix, Rachel Katzenellenbogen, and Harmit Malik

Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.

Click the arrow above to play, or right-click to download TWiV #135 (63 MB .mp3, 97 minutes).

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Weekly Science Picks

Roger – Atomic structure of adenovirus by cry0-EM (Science)
Harmit – Syncytin knockout mice show role for endogenous retroviral gene (PNAS)
 Vincent – Free science, one paper at a time by David Dobbs

Listener Pick of the Week

Mark  – Shot by Shot

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TWiV 134: Meet Ralph, your cruise director

norovirusHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Stephanie Karst

Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.

Click the arrow above to play, or right-click to download TWiV #134 (68 MB .mp3, 94 minutes).

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Weekly Science Picks

Stephanie – Effectors of the type I interferon response (Nature)
Dickson – Receptor for Ebola virus (PNAS)
Rich – A History of Vaccines
Alan – The Worst Journey in the World by Apsley Cherry-Garrard
Vincent – ASM Live 2011 webcast

Listener Pick of the Week

Sophie  – TED talk app for iPad and iPhone

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TWiV 133: The HIV hideout

Dr. Kathleen CollinsHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathleen Collins

Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.

Click the arrow above to play, or right-click to download TWiV #133 (42 MB .mp3, 87 minutes).

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Weekly Science Picks

Kathleen – TRIM5 is an innate immune sensor (Nature)
Rich – A Biologist’s Mothers Day Song (YouTube)
Alan – World of Viruses
Vincent – Magnet Balls (Amazon)

Listener Pick of the Week

Chris  – Periodic Tales by Hugh Aldersey-Williams

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TWiV 132: Virology 911

alfred sacchettiHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Alfred Sacchetti

Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.

Click the arrow above to play, or right-click to download TWiV #132 (48 MB .mp3, 100 minutes).

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Weekly Science Picks

Al – The Physics of Superheroes and NKT Watch
Dickson – Fibonacci Fun by Trudi Hammel Garland and Rachel Gage
Rich – Retraction Watch
Alan – Neil deGrasse’s comments on UFOs, argument from ignorance, and scientific method (YouTube)
Destanie – Microcosm by Carl Zimmer
Vincent – The intestinal microbiota and viral susceptibility

Listener Pick of the Week

Jim  – Extraordinary Measures

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