This Week in Virology

TWiV 613: Jenner, vaccines, and COVID-19

May 14, 2020

Vincent, Kathy and Rich explain the Jenner Institute’s SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 613 (63 MB .mp3, 106 min)
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COVID-19 brings out dark side of science (Mother Jones, Wired) 1:34
Jenner Institute COVID-19 vaccine (BioSpace) 11:11
Recombineering (Nucleic Acids Res) 13:48
Vaccines lecture (YouTube) 52:58
ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) 28:28
Chimpanzee adenovirus vector (PLoS One) 33:34
Ad-MERS vaccine protects monkeys (NIH) 28:08
Rapid COVID-19 vaccine development (Science) 43:56
Strategic approach to COVID-19 vaccines (Science) 48:19
NIH decision to stop remdesivir study (Stat) 53:16
80,000 flu deaths this winter (Stat) 55:09
Science and singing (YouTube) 1:16:55
COVID-19 at choir practice (Emerg Inf Dis) 1:22:00
Letters read on TWiV 613 36:56, 55:52
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 612: CEPI, preventing the next pandemic

May 12, 2020

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Download TWiV 612 (87 MB .mp3, 143 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 611: Corona and crowns

May 10, 2020

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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Download TWiV 611 (87 MB .mp3, 143 min)
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OSHA guidance for dentistry 33:16
COVID0-19 challenges for dentistry (J Dent Res) 45:20
COVID-19 and dentistry (Int J Env Res Pub Health)
Mouthrinses for dentistry (J Clin Med) 48:50, 54:08
Disingenuous plandemic documentary (Big Think) 1:29:32
Letters read on TWiV 611: 26:41, 1:12:18, 1:16:50
- Plain language talking points on virus origins 1:17:00, 1:20:40
Image credit
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 610: Coronavirus FAQ

May 7, 2020

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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FDA revises statement on antibody tests (FDA) 3:20
Serology-based tests for SARS-CoV-2 (Center for Health Security) 5:32
ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) 14:40
Global COVID-19 CFR (CEBM) 23:27
Debunking transmission mutation: TWiEVO 55 1:36:01
Letters read on TWiV 610 27:58
- Plain language answers to listener questions 1:10:42-1:34:16
- Question 1 – 1:14:55
- Question 2 – 1:28:19
- More on TWiV 611
Image credit
Kiki’s Comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 609: A coronavirus chronology with Susan Weiss

May 3, 2020

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Susan Weiss

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Download TWiV 609 (45 MB .mp3, 75 min)
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Coronaviruses by Susan Weiss (YouTube) 3:34
Forty years with coronaviruses (JEM) 4:10
No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) 13:04
CoV and antagonism of RNAse L (mBio) 47:19, 48:43
Exoribonuclease needed for MHV innate antagonism (J Virol) 47:19, 52:34
RNAse L and ADAR (eLife) 59:54
Emerging viruses respiratory award (Amer Lung Assoc) 1:08:11
Kiki’s Comments
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 608: Daniel Griffin’s COVID-19 clinical report

May 1, 2020

Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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Download TWiV 608 (35 MB .mp3, 57 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 607: Coronavirus epidemiology with Jeff Shaman

April 29, 2020

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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Download TWiV 607 (41 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 606: Evidence-based science and medicine for COVID-19

April 26, 2020

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin

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Download TWiV 606 (69 MB .mp3, 114 min)
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Links for this episode

Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) 45:06
Saliva is more sensitve than nasopharyngeal swab (medRxiv)48:48
NY serological survey results (NY Times) 57:36
FDA caveats on serological tests (FDA) 57:53
Federal guidelines on when to open 1:07:15
When to open: Roadmap, blog, video explainer 1:07:22
Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) 1:11:18
Lawmakers want human challenge studies (Science) 1:15:28
Letters read on TWiV 606
Image credit
Timestamps by Jolene. Thanks!
Kiki’s Comments – Summary of this episode

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 605: READDI for the next pandemic

April 23, 2020

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric, Mark Heise, and Nat Moorman

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Download TWiV 605 (32 MB .mp3, 53 min)
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Links for this episode

READDI.org 6:55
CEPI 20:43
DNDi 24:31
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection

April 21, 2020

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Download TWiV 604 (39 MB .mp3, 64 min)
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