This Week in Virology

TWiV 602: Coronavirus immunology with Stanley Perlman

April 16, 2020

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

Click arrow to play
Download TWiV 602 (45 MB .mp3, 74 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Perlman Laboratory 1:39
An Iowa Caucus of Viruses (TWiV 538) 2:00
Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) 28:07
T cell responses to respiratory CoV (Immunol Res) 19:13
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 601: Das coronavirus with Christian Drosten

April 14, 2020

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

Click arrow to play
Download TWiV 601 (34 MB .mp3, 56 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Das Coronavirus podcast 1:00
Identification of SARS-CoV in Germany (NEJM) 3:13
29 nt deletion in genome of SARS-CoV (Sci Rep) 34:20
382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 38:00
Virological assessment of COVID-19 patients (Nature) 26:29
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 600: SARS-CoV-2 – enter the Coronials

April 12, 2020

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

Click arrow to play
Download TWiV 600 (69 MB .mp3, 113 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 45:23
Recombination and mutation leading to SARS-CoV-2 (bioRxiv) 49:09
Letters read on TWiV 600 20:39, 31:47, 41:34, 42:48, 54:15
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 599: Coronavirus update – we need a plan

April 8, 2020

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

Click arrow to play
Download TWiV 599 (77 MB .mp3, 128 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) 2:39
Tiger at NY zoo positive for SARS-CoV-2 (NY Times) 28:30
IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) 36:00
Infection fatality rate for managing pandemic (virology blog) 40:39
Letters read on TWiV 599 32:36, 1:01:51
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 598: Who was that masked man? Coronavirus update with Daniel Griffin

April 5, 2020

Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Click arrow to play
Download TWiV 598 (70 MB .mp3, 115 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Restricted dispensing of Plaquenil in NY state 22:00
Virology of COVID-19 patients (Nature) 31:37
Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv) 36:23
Cloth face masks for all of US (NY Times) 40:34
Masks and respiratory virus shedding (Nat Med) 41:30
50 million face masks to Japanese households (Kyodo News) 47:50
More than you want to know about face masks (Slate Star Codex) 47:58
Why is COVID-19 less severe in children? (virology blog) 51:05
Tracking SARS-CoV-2 in sewage (UM) 52:10
1918 flattening the curve (Nat Geo) 53:11
COVID near you 54:30
Pandemic stops polio eradication (Science) 55:37
SARS-CoV-2 vaccine patch in mice (U Pitt) 1:00:23
Letters read on TWiV 595 1:03:32
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 597: A lot of immunology and some COVID-19 with Jon Yewdell

April 3, 2020

Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jon Yewdell

Click arrow to play
Download TWiV 597 (69 MB .mp3, 115 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 596: COVID-19 – an ounce of prevention

April 1, 2020

TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Click arrow to play
Download TWiV 596 (73 MB .mp3, 121 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Emergency use of hydroxychloroquine (FDA) 16:01
Trial of hydroxycholorquine in COVID-19 patients (China, France) 18:33, 20:43
COVID-19 in critically ill patients, Seattle (NEJM) 22:42
Feasibility of convalescent plasma therapy for COVID-19 (medRxiv) 24:14
Letters read on TWiV 596 29:00
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 595: Coronavirus update – Daniel Griffin MD in the parking lot

March 29, 2020

Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Click arrow to play
Download TWiV 595 (71 MB .mp3, 117 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV Special: Conversation with a COVID-19 patient, Ian Lipkin

March 28, 2020

Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.

Hosts: Vincent Racaniello

Guest: W. Ian Lipkin

Click arrow to play
Download TWiV Special (42 MB .mp3, 69 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Center for Infection and Immunity 00:25
Control the Contagion videos 35:24
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV Special: Coronavirus update with Mark Denison, MD

March 26, 2020

Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

Hosts: Vincent Racaniello

Guest: Mark Denison

Click arrow to play
Download TWiV Special (32 MB .mp3, 53 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]