This Week in Virology

TWiV 594: Coronavirus update – Shelter in place

March 25, 2020

A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Coronavirus test kit 17:46
Rapid SARS-CoV-2 serological assay (medRxiv) 19:27
Is Dr. Fauci in trouble? (NY Times) 20:17
FDA approves emergency use of convalescent serum (FDA) 21:46
Image by Michele Banks
Letters read on TWiV 594 14:09, 21:22, 28:43
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 593: Coronavirus update – flatten the curve

March 22, 2020

Daniel Griffin joins Ori and the TWiV team for an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin, Ori Lieberman, and Valeria Cagno

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Download TWiV 593 (84 MB .mp3, 139 min)
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Pregnancy and COVID-19 papers (1, 2, 3, 4, 5) 48:45
Second dog infected with SARS-CoV-2 (ProMedMail) 53:13
Italian site with infographic in English 1:16:25
Image by Michele Banks
Letters read on TWiV 593 1:13:35, 1:17:01
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 592: Coronavirus update – dangerous curve ahead

March 19, 2020

Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Ori Lieberman

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Download TWiV 592 (69 MB .mp3, 114 min)
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Scary modeling (Imperial College London) 3:47
Avigan vs SARS-CoV-2 (NHK) 9:57
SARS-CoV-2 mRNA vaccine (Clinical Trials) 14:52
SARS-CoV-2 stability (NEJM) 21:23
Pediatric COVID-19 (one, two) 21:38
SARS-CoV-2 asymptomatic infection (one, two) 24:38
CDC data on SARS-CoV-2 CFR (MMWR) 26:20
Hydroxycholorquine trial for COVID-19 (Mediterranee-infection) 11:50
Macaque SARS-CoV-2 immunity (bioRxiv) 35:12
Image by Michele Banks
Letters read on TWiV 592 38:17
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV Special: SARS-CoV-2 epidemiology with Stephen Morse

March 18, 2020

Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic.

Hosts: Vincent Racaniello

Guest: Stephen Morse

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Download TWiV Special (37 MB .mp3, 61 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV Special: A medical student perspective on COVID-19

March 17, 2020

Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.

Hosts: Vincent Racaniello

Guest: Ori Lieberman

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Download TWiV Special (30 MB .mp3, 49 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 591: Coronavirus update with Ralph Baric

March 15, 2020

Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ralph Baric

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Download TWiV 591 (75 MB .mp3, 123 min)
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Aerosol and surface stability of SARS-CoV-2 (medRxiv) 1:04:15
Clinical course and risk factors for COVID-19 (Lancet, pdf) 1:08:35
Face mask use during SARS-CoV outbreak (EID) 1:37:03
COVID-19 and Italy (Lancet) 1:09:59
Donning and doffing PPE (YouTube)
Letters read on TWiV 591 1:10:57
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 590: COVID-19 and coronavirus – we have mail

March 8, 2020

The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 590 (76 MB .mp3, 127 min)
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Stanley Perlman answers CoV questions (Boston Globe) 2:05:03
Fist bump (Am J Infect Control) 1:36:25
Joint WHO-China report (pdf) 8:26
Second coronavirus (LA Times) 13:35
Response to second coronavirus (virological.org) 13:44
COVID-19 animal models (STAT) 19:00
Clinical predictors of COVID-19 mortality (Inten Care Med) 20:56
CoV by the numbers (NY Times) 10:55, 22:05
Contamination of bar soaps (Microbios) 32:24
SARS-CoV-2 vaccine timeline (NPR) 1:25:10
How new vaccines are developed (GSK) 1:24:32
SARS among critical care nurses (Emerg Inf Dis) 1:56:34
How churches prevent SARS-CoV-2 spread (NPR) 2:01:05
Image credit
Letters read on TWiV 590 31:25
Transcript of this episdode (pdf and html)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV Special: Coronavirus SARS-CoV-2 and COVID-19 update

March 4, 2020

Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy.

Host: Vincent Racaniello

Guests: Daniel Griffin and Valeria Cagno

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Download TWiV Special (35 MB .mp3, 58 min)
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Transcript of this episode (pdf and html)

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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 589: Coronavirus update – it could be bad

March 1, 2020

Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.

Hosts: Vincent Racaniello and Rich Condit

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Download TWiV 589 (51 MB .mp3, 84 min)
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WHO CoV sitreps 4:21
How to Prepare for the Coronavirus (NY Times) 12:55
Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) 23:30
Cruise ship a/c could promote virus spread (Purdue news) 1:14:16
Open source SARS-CoV-2 peptide vaccine design (GitHub)
Image credit
Letters read on TWiV 589 27:03
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 588: Coronavirus update – Save the pangolin!

February 23, 2020

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Download TWiV 588 (91 MB .mp3, 151 min)
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