TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection

April 21, 2020

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Download TWiV 604 (39 MB .mp3, 64 min)
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Links for this episode

  • Nonpathogenic enteroviruses to prevent human disease (pdf) 6:13
  • OPV for COVID-19 (pdf) 17:56
  • Enteroviruses to prevent human infections (pdf) 7:08
  • Image credit
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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5 comments on “TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection

  1. Great interview! Makes me hopeful.
    Fascinating story about his family, would love to read a book about vaccine development centered around his family, especially Maria Voroshilova, can Carl Zimmer oder Sid Mukherjee write that, please? 🙂

  2. Prof. Chumakov mentioned that a large scale clinical trial showed that an OPV (Oral Polio Vaccine) reduced seasonal flu by 3.8 fold (~07:44 in the interview)?

    How does that compare to the effectiveness vs IFV which ranges between 30-50% effective (depending on season and strain)? I’m starting to search through NCBI for papers relating to this. Any additional recommendations for research on the background of this fascinating finding?

    And I hope the study into OPV as a possible prophylactic treatment against SARS2 will prove promising.