In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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• Antiviral antibodies early in US outbreak (CID) 5:41
• Serologic testing of US blood donations (CID) 6:44
• The virus, what went wrong (PBS) 7:44
• MIS-C in children (JAMA) 8:55
• Myocarditis in competitive athletes (JAMA) 10:42
• ER visits for suspected suicide (MMWR) 13:13
• Delta variant in Scotland (Lancet) 15:44
• Novavax phase 3 results (Novavax) 18:29
• Vaccine coverage in pregnant women (MMWR) 21:00
• Early mAb reduces hospitalization and mortality (CID) 22:06
• Regen-Cov trial results (Regeneron) 23:58
• Guidance on postacute sequelae (CDC) 26:44
• Letters read on TWiV 770 30:27
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 767 (24 MB .mp3, 40 min)
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Links for this episode

• COVID-19 treatment guidelines (IDSA)
• Hospitalization of adolescents (MMWR)
• Estimating dynamics from viral load (Science)
• Incidence according to antibody status (Lancet)
• Reinfections in Italy (JAMA)
• Need for vaccination in previously infected (medRxiv)
• Assessment of protection against reinfection (ACC)
• Antimicrobial use in hospitalized patients (Lancet)
• Effect of single dose ivermectin (Viruses)
• Aspirin in hospitalized patients (medRxiv)
• Letters read on TWiV 767
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: David Fajgenbaum

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Download TWiV 766 (68 MB .mp3, 114 min)
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Links for this episode

• CORONA project 18:58, 46:32
• Center for Cytokine Storm Treatment & Laboratory 1:54, 20:29
• Castleman Disease Collaborative Network 2:10, 5:41, 8:52
• Chasing My Cure 2:51, 5:15
• Letters read on TWiV 766 1:01:39
• Timestamps by Jolene. Thanks!

Weekly Picks 1:19:28

Brianne – How Giraffes Beat High Blood Pressure
Kathy – Orangutan optical illusion
Vincent – Two quotes from Chasing My Cure by David Fajgenbaum

John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.

David: Never stop questioning and always follow the data.

Listener Picks

Greg – Stewart Lee on Loch Ness monster

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 764 (24 MB .mp3, 40 min)
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Links for this episode

• Effects of vaccines and NPIs (JAMA) 2:23
• Guidance on summer camps (CDC) 6:45
• Antibody testing not recommended (FDA) 10:11
• Antigen testing at a music event (Lancet) 10:25
• Methotrexate and vaccine immunogenicity (Ann Rheum Dis) 18:19
• Colchicine phase 3 results (Lancet Resp Med) 24:39
• Small airway disease a post-acute sequelae (medRxiv) 26:43
• Letters read on TWiV 764 33:35
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]