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Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.

Note: Daniel’s update is in the audio only version of this episode.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric

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Download TWiV 626 (98 MB .mp3, 163 min)
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Intro music is by Ronald Jenkees

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Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.

Hosts: Vincent Racaniello and Rich Condit

Guest: Frederick A. Murphy

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Download TWiV 625 (60 MB .mp3, 100 min)
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Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

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Download TWiV 624 (74 MB .mp3, 123 min)
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Intro music is by Ronald Jenkees

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Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Peter Daszak

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Download TWiV 623 (41 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees

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CoV_bank

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Download TWiV 622 (41 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

CoV_bank

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Download TWiV 621 (91 MB .mp3, 152 min)
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Intro music is by Ronald Jenkees
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CoV_bank

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Download TWiV 620 (67 MB .mp3, 111 min)
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Intro music is by Ronald Jenkees.

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Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Download TWiV 619 (43 MB .mp3, 72 min)
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Intro music is by Ronald Jenkees.

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From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Download TWiV 615 (35 MB .mp3, 58 min)
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Intro music is by Ronald Jenkees.

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Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 617 (91 MB .mp3, 152 min)
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Links for this episode

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv