This Week in Virology

TWiV 616: Singing about coronavirus

May 21, 2020

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna’s mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 616 (62 MB .mp3, 103 min)
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Intro music is by Ronald Jenkees.

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TWiV 615: Peter Daszak of EcoHealth Alliance

May 19, 2020

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Download TWiV 615 (22 MB .mp3, 36 min)
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Intro music is by Ronald Jenkees.

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TWiV 614: COVID Tetris – Test, trace, isolate

May 17, 2020

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 614 (100 MB .mp3, 167 min)
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Triple therapy for COVID-19 (Lancet) 33:47
Virology podcast goes viral (Thalia Gigerenzer) 45:22
Paul Stays Home (pdf) 48:30
Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) 51:01
Mumbai engulfed by CoV (NY Times) 58:13
All must be vaccinated (Stat) 1:00:23
FDA concerns with Abbott test (FDA) 1:03:11
How US lost 6 weeks (BBC) 1:11:26
Letters read on TWiV 614 26:35, 40:21, 1:12:22
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 613: Jenner, vaccines, and COVID-19

May 14, 2020

Vincent, Kathy and Rich explain the Jenner Institute’s SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 613 (63 MB .mp3, 106 min)
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COVID-19 brings out dark side of science (Mother Jones, Wired) 1:34
Jenner Institute COVID-19 vaccine (BioSpace) 11:11
Recombineering (Nucleic Acids Res) 13:48
Vaccines lecture (YouTube) 52:58
ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) 28:28
Chimpanzee adenovirus vector (PLoS One) 33:34
Ad-MERS vaccine protects monkeys (NIH) 28:08
Rapid COVID-19 vaccine development (Science) 43:56
Strategic approach to COVID-19 vaccines (Science) 48:19
NIH decision to stop remdesivir study (Stat) 53:16
80,000 flu deaths this winter (Stat) 55:09
Science and singing (YouTube) 1:16:55
COVID-19 at choir practice (Emerg Inf Dis) 1:22:00
Letters read on TWiV 613 36:56, 55:52
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 612: CEPI, preventing the next pandemic

May 12, 2020

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Download TWiV 612 (87 MB .mp3, 143 min)
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Intro music is by Ronald Jenkees.

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TWiV 611: Corona and crowns

May 10, 2020

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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Download TWiV 611 (87 MB .mp3, 143 min)
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OSHA guidance for dentistry 33:16
COVID0-19 challenges for dentistry (J Dent Res) 45:20
COVID-19 and dentistry (Int J Env Res Pub Health)
Mouthrinses for dentistry (J Clin Med) 48:50, 54:08
Disingenuous plandemic documentary (Big Think) 1:29:32
Letters read on TWiV 611: 26:41, 1:12:18, 1:16:50
- Plain language talking points on virus origins 1:17:00, 1:20:40
Image credit
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 610: Coronavirus FAQ

May 7, 2020

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 610 (60 MB .mp3, 99 min)
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FDA revises statement on antibody tests (FDA) 3:20
Serology-based tests for SARS-CoV-2 (Center for Health Security) 5:32
ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) 14:40
Global COVID-19 CFR (CEBM) 23:27
Debunking transmission mutation: TWiEVO 55 1:36:01
Letters read on TWiV 610 27:58
- Plain language answers to listener questions 1:10:42-1:34:16
- Question 1 – 1:14:55
- Question 2 – 1:28:19
- More on TWiV 611
Image credit
Kiki’s Comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 609: A coronavirus chronology with Susan Weiss

May 3, 2020

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Susan Weiss

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Download TWiV 609 (45 MB .mp3, 75 min)
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Coronaviruses by Susan Weiss (YouTube) 3:34
Forty years with coronaviruses (JEM) 4:10
No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) 13:04
CoV and antagonism of RNAse L (mBio) 47:19, 48:43
Exoribonuclease needed for MHV innate antagonism (J Virol) 47:19, 52:34
RNAse L and ADAR (eLife) 59:54
Emerging viruses respiratory award (Amer Lung Assoc) 1:08:11
Kiki’s Comments
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 608: Daniel Griffin’s COVID-19 clinical report

May 1, 2020

Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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Download TWiV 608 (35 MB .mp3, 57 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 607: Coronavirus epidemiology with Jeff Shaman

April 29, 2020

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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Download TWiV 607 (41 MB .mp3, 68 min)
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