TWiV 620: Antibodies and T cells in COVID-19 patients

May 29, 2020

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

Click arrow to play
Download TWiV 620 (67 MB .mp3, 111 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees.

Send your virology questions and comments to

Leave a Reply

Your email address will not be published. Required fields are marked *

18 comments on “TWiV 620: Antibodies and T cells in COVID-19 patients

  1. PattiM May 30, 2020

    The JHU database has added CFR to its daily reported cases database. Can an epidemiologist discuss the fact that the mean CFR in the U.S. is 3.55 whereas that in Australia is 1.79?

  2. Robert L. Colvard, Jr May 30, 2020

    Yes, maybe I am mistaken but I was getting the idea from your TWIV 620 program that Covid-19 was presenting similarly, immunologically speaking, to HIV. In other words one of your guests seemed to be suggesting that we may not be able to develop a vaccine for SARS-CoV-2. There seemed to be a high concern with developing antivirals by the Fall. I was just reading an article in “The Journal of Allergy and Clinical Immunology”, DOI:, that suggests that there are people with immunodeficiencies such as primary antibody deficiencies (PADs), common variable immune deficiencies (CVIDs)-agammaglobulinemia, X-linked and autosomal recessive, that make them susceptible to severe respiratory distress and multiorgan failure. I was getting the idea that the nature of the virus was possibly killing T-Cells like HIV does. this article does not seem to support that contention. Did I miss something?

  3. Randall von Wedel, Ph.D. May 31, 2020

    Excellent. Thank you

  4. Philippe Raimbault May 31, 2020

    Hello twiv this is a great vidoe of ace2 receptors functions and the link with sars cov2 infection, check it out.

  5. Steve Hawkins Jun 1, 2020

    It’s not often that I listen to a long podcast and then let out an involuntary cry of dismay, when it finishes too soon!

    Jon Yewdell really does inspire the team into quite extraordinarily spellbinding and imaginative conversations!

    Utterly brilliant! I can’t claim to be able to follow more than a small part of it all, but the team’s collective enthusiasm for the wonders of science and Nature, are utterly contagious in themselves. I thoroughly agree with Jon Yewdell, that one must study broadly, across the genres of science, to begin to take in just how incredible our living planet and every one of its cells and viruses, really is.


    Many thanks to all.

  6. Priscilla Jun 6, 2020

    At the 11:00 mark, Nobel Laureate Ralph Steinman and his work on dendritic cells is mentioned. His mentee Sarah Schlesinger tells a lovely story of him in a Moth Radio Hour storytelling:

  7. Wow! Mind-blowingly informative. What a high.

  8. Ed Chiodo Aug 26, 2021

    Mostly over my head but GREAT listening to these eloquent experts.
    Any subsequent thoughts on whether VAXART’s approach has merit?