TWiV 845: COVID-19 clinical update #94 with Dr. Daniel Griffin

In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients.

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Intro music is by Ronald Jenkees

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TWiV 844: Paul Offit on children, COVID, and boosters

Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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Weekly Picks 1:28:48

Brianne – Virus snowflakes
Dickson – The Year in Pictures 2021
Vincent – Our Life is Plasticized

Listener Picks

Gerry – Dan Barouch: COVID-19 Vaccine Development
Louise – Pandora’s Lab by Paul Offit

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin

In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV 842: The clot thickens

TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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Weekly Picks 58:41

Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year
Kathy – Snake dietary diversity
Vincent – Alfred Wegener Institute on Instagram

Listener Picks

Niclas – Once upon a time… Life

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 841: Unmasking immunity

TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:22:29

Dickson – Cities at Night
Amy – I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds
Rich – International Dark Sky Association
Vincent – SARS-CoV-2 variants

Listener Picks

Keith – Ventusky

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin

In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV 839: The long and the short of it: get vaccinated

TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:24:27

Kathy – CDC U-M flu report (lay version, MMWR)
Rich – Thagomizer
Alan – Descent into Darkness by Edward Raymer
Vincent – Funding: Blinding peer review

Listener Picks

Lynne – ACE2 in chewing gum

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 838: The magic virus bus

The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi,

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Weekly Picks 1:18:48

Dickson – Plant Habitat-04
Brianne – The Coronavirus in a Tiny Drop
Rich – Prophet in Purgatory by Jon Cohen
Vincent – “ ’—All You Zombies—’ ” by Robert A. Heinlein (pdf)

Listener Picks

Mike – The Coronavirus in a Tiny Drop

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 837: COVID-19 clinical update #91 with Dr. Daniel Griffin

In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 836: OMG, Omicron!

TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:37:49

Brianne – Immune
Kathy – Elizabeth Lee Hazen and Rachel Fuller Brown, discoverers of nystatin one and two
Alan – Four Lost Cities by Analee Newitz
Vincent – Deadly Choices by Paul Offit

Listener Picks

Ryan – Ronny Jackson (one and two)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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