Louise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2.
Nels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness.
TWiEVO 77: The mutations of our lives
- April 26, 2022
- Tagged as: age, cancer, evolution, germline mutation, mammal, mutation, mutation rate, natural selection, somatic mutation
Alex joins Nels and Vincent to discuss his work which demonstrates that somatic mutation rates scale with lifespan in mammals.
TWiEVO 76: One-step symbiosis
- March 22, 2022
- Tagged as: E. coli, evolution, mutualism, natural selection, reduced genome, stinkbug, symbiont
Nels and Vincent describe how a single amino acid change can allow E. coli to replace the essential gut symbiont of the stinkbug Plautia stali.
TWiEVO 75: Even the BANAL coronaviruses are interesting
- February 24, 2022
- Tagged as: coronavirus, Laos, pandemic, Rhinolophus bat, SARS-CoV-2, spillover, virology, virus, viruses, zoonosis
Nels and Vincent review isolation of SARS-CoV-2-like viruses from bats in Laos that can replicate in human cells.
TWiEVO 74: On racism, not race with Joe Graves
- February 3, 2022
- Tagged as: evolution, natural selection, race, racism
Joe Graves joins Nels and Vincent to discuss his career in evolutionary biology and his recent book that answers questions about race and racism.
TWiEVO 73: With a little help from your hosts
- December 28, 2021
- Tagged as: coronavirus, COVID-19, evolution, fitness, natural selection, Omicron, pandemic, RNA insertion, SARS-CoV-2
Nels and Vincent review three aspects of SARS-CoV-2: phylogenetics of Omicron, a two-step fitness selection for SARS-CoV-2 variants, and putative RNA insertions from host genomes.
Nels and Vincent discuss evolutionary evidence for an epidemic of coronavirus infection over 20,000 years ago in East Asia, and reconstruction of the membrane differences between bacteria and Archaea reveals unexpected differences in permeability.
Nels and Vincent explain a method to calculate the mutation rate of SARS-CoV-2, and the role of a single amino acid change in spike in enhancing fitness of the delta variant and enabling it to out-compete the alpha variant.
TWiEVO 70: On Life’s Edge with Carl Zimmer
- August 3, 2021
- Tagged as: Carl Zimmer, COVID-19, evolution, natural selection, pandemic, science communication, virus
Carl Zimmer joins Nels to talk about science writing, science communication, viruses, and his new book, On Life’s Edge.
