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Tag: positive selection

  • Episode

TWiEVO 65: Variants in the mist

  • February 25, 2021
  • Tagged as: adaptive changes, COVID-19, evolution, evolutionary sweep, natural selection, positive selection, spillover, variant of concern, zoonosis

Nels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern.

1 Reply
  • Episode

TWiEVO 52: Virus evolution by land and by sea and by CoV

  • February 26, 2020
  • Tagged as: ACE2, bat, coronavirus, CoV, evolution, pangolin, positive selection, receptor binding domain, SARS-CoV-2, spike glycoprotein, virus, viruses, zoonosis

Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

5 Replies
  • Episode

TWiEVO 5: Looking at straw colored fruit bats through a straw

  • February 20, 2016
  • Tagged as: bat, Ebolavirus, filovirus, host-virus conflict, NPC1, positive selection, receptor, viral, virology, virus, virus entry, viruses
TWiEVO

Sara and Kartik join Nels and Vincent to talk about how the filovirus receptor NPC1 regulates Ebolavirus susceptibility in bats.

2 Replies

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