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Tag: mutation

  • This Week in Evolution

TWiEVO 84: Decoding our defenses to the Black Death

  • November 8, 2022
  • Tagged as: ancient DNA, black death, evolution, mutation, natural selection, positive selection, Yersinia pestis

Nels and Vincent review the use of ancient DNA to identify loci that may have been under selection during the Black Death by studying populations before, during, and after the pandemic.

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  • This Week in Evolution

TWiEVO 81: Evolution’s new and improved slime molds

  • August 24, 2022
  • Tagged as: Dictyostelium, evolution, gene duplication, mutation, natural selection, neofunctionality, slime mold

Nels and Vincent discuss how duplication of a gene encoding a transcription factor led to evolution of a novel cell type in the slime mold Dictyostelium.

2 Replies
  • This Week in Evolution
  • This Week in Evolution

TWiEVO 80: Viruses of a feather bottleneck together

  • August 1, 2022
  • Tagged as: evolution, influenza virus H5N1, mumps virus, mutation, natural selection, phylogenomics, SARS-CoV-2, transmission bottleneck, virus

Louise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2.

2 Replies
  • This Week in Evolution
  • This Week in Evolution

TWiEVO 77: The mutations of our lives

  • April 26, 2022
  • Tagged as: age, cancer, evolution, germline mutation, mammal, mutation, mutation rate, natural selection, somatic mutation

Alex joins Nels and Vincent to discuss his work which demonstrates that somatic mutation rates scale with lifespan in mammals.

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  • Episode

TWiVEO 67: Corona chameleon

  • April 22, 2021
  • Tagged as: B.1.1.7, coronavirus, COVID-19, mutation, natural selection, pandemic, RNA recombination, variants of concern

Nels and Vincent review evidence for recombinant SARS-CoV-2 genomes arising in the B.1.1.7 lineage within the United Kingdom.

2 Replies
  • Episode

TWiEVO 59: The hypothesis giving tree

  • August 28, 2020
  • Tagged as: amoeba, COVID-19, evolution, giant virus, mutation, natural selection, ORFan, pandemic, SARS-CoV-2

Nels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins.

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  • Episode

TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms

  • June 24, 2020
  • Tagged as: deep mutational scanning, evolution, mutation, natural selection, receptor binding domain, SARS-CoV-2

Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

3 Replies
  • Episode

TWiEVO 32: Never not neutral

  • June 19, 2018
  • Tagged as: adaptation, evolution, mutation, natural selection, neutral theory of evolution, population genetics, spandrel, TWiEVO

Matt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data.

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  • Episode

TWiEVO 25: Pigeons show the way

  • November 22, 2017
  • Tagged as: drift, evolution, extinction, genome, mitochondrial genome, mutation, natural selection, passenger pigeon, population

Nels and Vincent discuss a genomic analysis of the passenger pigeon, which shows that species with large and stable populations may be at risk of extinction after a sudden environmental change.

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  • Episode

TWiEVO 2: Faster than a speeding virus

  • December 26, 2015
  • Tagged as: APOBEC, enzyme, evolution, HIV, human immunodeficiency virus, mutation, mutation rate, viral, virology, virus, viruses
TWiEVO

Nels and Vincent talk about how a cellular enzyme contributes to the very high mutation rate of human immunodeficiency virus type 1.

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