Nels and Vincent provide insights into the mystery of mouse mummies on the summits of >6000 m Andean volcanoes, including whether they were living there and if so why?
Nels and Vincent discuss the observation that cells on a boundary of a solid tumor have higher growth rates compared to those in the center and how to model this difference using genome sequencing data.
Nels and Vincent review a study of the dogs of Chernobyl which reveals that genetically distinct populations with different amounts of western breed contributions to their genomes, the first step in assessing the effects of exposure to long-term ionizing radiation.
Nathan joins Nels and Vincent to discuss his approach to understanding how species adopt novel traits to overcome challenges, and its application to identifying coding and noncoding sequence changes that underlie mammalian hairlessness. Hosts: Nels…
TWiEVO 86: Pulling out the stops in genetic code evolution
- February 2, 2023
- Tagged as: anticodon, eRF1, evolution, natural selection, protein synthesis, protist, stop codon, tRNA
Nels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop.
Nels and Vincent discuss the use of genome sequence data for over 4,000 domestic, semi-feral, and wild canids to understand the genetic drivers of canine behavior.
Florian Maderspacher from Current Biology joins Nels and Vincent to discuss a special issue of the journal on birds.
TWiEVO 82: A genetic hack for the human brain
- September 22, 2022
- Tagged as: evolution, frontal cortex, H. sapiens, neocortex, neurogenesis, TKTL1
Nels and Vincent consider evidence that a single amino acid change in the TKTL1 gene might have led to greater neurogenesis in the frontal cortex of modern humans compared with Neanderthals.
Louise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2.
Nels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness.