Nels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern.
TWiEVO 58: Not all coronaviruses ACE2 the test
- August 13, 2020
- Tagged as: ACE2, evolution, Rhinolophus bats, Sarbecovirus, SARS-CoV-2, spillover, viral, virology, virus, viruses, zoonosis
Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.
TWiEVO 52: Virus evolution by land and by sea and by CoV
- February 26, 2020
- Tagged as: ACE2, bat, coronavirus, CoV, evolution, pangolin, positive selection, receptor binding domain, SARS-CoV-2, spike glycoprotein, virus, viruses, zoonosis
Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.