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Tag: variants of concern

  • This Week in Evolution
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TWiEVO 79: When the immune system is away, SARS-CoV-2 will play

  • July 2, 2022
  • Tagged as: antibody evasion, chronic infection, coronavirus, COVID-19, evolution, fitness, immunocompromised, natural selection, pandemic, SARS-CoV-2, variants of concern

Nels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness.

3 Replies
  • This Week in Evolution

TWiEVO 78: The virus daily double

  • May 26, 2022
  • Tagged as: coronavirus, COVID-19, evolution, monkeypox, natural selection, negative selection, pandemic, positive selection, SARS-CoV-2, smallpox, spike protein, variants of concern

Nels and Vincent provide an update on cases of monkeypox, and summarize a biochemical view of three changes in the SARS-CoV-2 spike protein that may balance positive and negative selection.

1 Reply
  • Episode

TWiVEO 67: Corona chameleon

  • April 22, 2021
  • Tagged as: B.1.1.7, coronavirus, COVID-19, mutation, natural selection, pandemic, RNA recombination, variants of concern

Nels and Vincent review evidence for recombinant SARS-CoV-2 genomes arising in the B.1.1.7 lineage within the United Kingdom.

2 Replies
  • Episode

TWiEVO 66: SARS-2-mouse

  • March 25, 2021
  • Tagged as: B1.351, coronavirus, COVID-19, evolution, mouse, natural selection, P.1, pandemic, SARS-CoV-2, variants of concern, virus host range

Nels and Vincent review a preprint demonstrating that changes in the genomes of the SARS-CoV-2 variants B1.351 and P.1 allow the viruses to reproduce in mouse cells in culture and in laboratory mice.

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