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Tag: mutation rate

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TWiEVO 77: The mutations of our lives

  • April 26, 2022
  • Tagged as: age, cancer, evolution, germline mutation, mammal, mutation, mutation rate, natural selection, somatic mutation

Alex joins Nels and Vincent to discuss his work which demonstrates that somatic mutation rates scale with lifespan in mammals.

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  • Episode

TWiEVO 71: Faster than a speeding coronavirus

  • September 26, 2021
  • Tagged as: alpha variant, coronavirus, COVID-19, delta variant, evolution, mutation rate, natural selection, pandemic, SARS-CoV-2, viral fitness

Nels and Vincent explain a method to calculate the mutation rate of SARS-CoV-2, and the role of a single amino acid change in spike in enhancing fitness of the delta variant and enabling it to out-compete the alpha variant.

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  • Episode

TWiEVO 38: Evolving to evolve

  • December 24, 2018
  • Tagged as: anti-evolution drug, antibiotic resistance, bacteria, evolution, evolvability, Mfd protein, mutagenesis, mutation rate, RpoB, transcription-coupled repair, UvrA

Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics.

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  • Episode

TWiEVO 2: Faster than a speeding virus

  • December 26, 2015
  • Tagged as: APOBEC, enzyme, evolution, HIV, human immunodeficiency virus, mutation, mutation rate, viral, virology, virus, viruses
TWiEVO

Nels and Vincent talk about how a cellular enzyme contributes to the very high mutation rate of human immunodeficiency virus type 1.

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