TWiV 955: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 954: Speculating sarbecovirus spillovers with Michael Letko

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Michael Letko

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  • Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV 4:55
  • Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) 17:32
  • ACE2-dependent sarbecovirus in Russian bats (PLoS Path) 21:37
  • Letters read on TWiV 954 1:14:04
  • Timestamps by Jolene. Thanks!

Weekly Picks 1:31:26

Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs  Jupiter,  Lunar Eclipse Blood Moon, Ice Giant
Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1

Listener Pick

Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 953: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 952: Jake Scott put the ID in COVID-19

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

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Weekly Picks 1:30:22

Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich – Wilderness Safaris Photographic Competition 2022
Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent – Andrea Camillieri and his protagonist Inspector Montalbano

Listener Pick

Frank – Economics for the Future: Beyond the Superorganism
Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 951: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 950: Prion diseases with Richard Knight

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Intro music is by Ronald Jenkees

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TWiV 949: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 948: Breathless with David Quammen

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Weekly Picks 1:34:15

David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich – “Elementary” TV series
Vincent – Stop passing the buck on intro science

Listener Pick

Rich – Consensus

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 947: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 946: Poo versus flu

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker

Guest: Angela Mingarelli

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Weekly Picks 1:23:20

Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich – Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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