Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michael Letko
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Download TWiV 954 (63 MB .mp3, 104 min)
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Links for this episode
- Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV 4:55
- Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) 17:32
- ACE2-dependent sarbecovirus in Russian bats (PLoS Path) 21:37
- Letters read on TWiV 954 1:14:04
- Timestamps by Jolene. Thanks!
Weekly Picks 1:31:26
Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs Jupiter, Lunar Eclipse Blood Moon, Ice Giant
Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1
Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks
Intro music is by Ronald Jenkees
Send your virology questions and comments to email@example.com
Regarding Rabies infection and vaccination –
Rabies vaccine after exposure to an infected individual will not prevent infection (and eventual death). If an individual has an exposure the medical treatment is to give Rabies Immunoglobulin. The IgG will provide protection from the active infection while vaccination does the job of preventing future infections.
Sorry to be pedantic but the difference is very important and potentially life saving
Please check your sources, Peter Fox. Post-exposure vaccination is usually highly effective in preventing the rabies disease and associated death.
Never mind. Yes, immunoglobulin is given along with the first vaccine dose 🙂
Vincent…..as a long time listener etc etc i was interested in your reading choice of The Shape Of Water/Andrea Camillera. I just had to recommend another author in the same vane (but almost better IMHO)…that of Donna Leone and her inspector Guido Brunetti, set in Venice. Pick any title and you will read them all…….as I did.
wishing many hours of happy reading. CHRIS ILIFFE