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Tag: cell entry

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TWiV 954: Speculating sarbecovirus spillovers with Michael Letko

  • November 13, 2022
  • Tagged as: ACE2, cell entry, coronavirus, COVID-19, Khosta virus, pandemic, RBD, sarbecovirus, SARS-CoV-2, Tmprss2, trypsin, viral, virology, virus, viruses

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

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  • Netcast

TWiV 486: Sean Whelan on being haploid

  • March 25, 2018
  • Tagged as: cell entry, ebolavirus, haploid screen, human ERV K, Lassa virus, Lujo virus, retrovirus gene trap, viral, virology, virus, virus receptor, viruses, VSV

Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.

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  • Netcast

TWiV 295: A nonslip grippe and Lassa’s LAMP

  • July 27, 2014
  • Tagged as: a-dystroglycan, arenavirus, cell entry, ferret, fusion, gain of function, haploid genetic screen, hemorrhagic fever, influenza, LAMP, Lassa virus, miRNA, receptor, viral, virology, virus

The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.

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