TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.
TWiV 675: Forget what you’ve herd about immunity
- October 25, 2020
- Tagged as: ACE2, coronavirus, COVID-19, entry protein, neuropilin, pandemic, SARS-CoV-2, Vaccine, viral, virology, virus, viruses
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.
TWiV 626: Ralph Baric and fancy ferrets
- June 14, 2020
- Tagged as: ACE2, coronavirus, COVID-19, mink, mouse model, pandemic, SARS-CoV-2, transmission, Vaccine, viral, virology, virus, viruses
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.
TWiV 616: Singing about coronavirus
- May 21, 2020
- Tagged as: ACE2, chorus, cigarette smoke, COVID-19, Moderna, mRNA vaccine, pandemic, SARS-CoV-2, viral, virology, virus, viruses
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna’s mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.
TWiV 588: Coronavirus update – Save the pangolin!
- February 23, 2020
- Tagged as: ACE2, China, coronavirus, CoV, COVID-19, epidemic, evolution, furin, pangolin, pneumonia, receptor binding domain, respiratory aerosol, SARS-CoV-2, spike glycoprotein, viral, virology, virus, viruses, Wuhan, zoonosis
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.
Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.
Inside a BSL-4
