TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.
John writes: Hi Twiv! I’m wondering if I can make a request. My wife’s name is Amy and she is one of your biggest fans. She’s a physician and listens to your podcast religiously. She…
Clarissa writes: Hi Rich, I listened to TWIV yesterday. Very good discussion and explanations. Thank you. The discussions are still ongoing here because now Russia decides to go forward with a one-dose vaccine, Sputnik light….
Anon writes:Hello TWIV: My father was recently diagnosed with plasmablastic lymphoma. He received his first dose of the Moderna COVID vaccine three weeks before his diagnosis. I know that some people have had a lymphatic…
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.
Andreas writes: <Long Story short: Rationale for the broad spectrum antiviral activity of Niclosamide: it’s a biophysical proton “shuttler” … no biological target required> Hi Twivoids – I am a Virologist by training and used…
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients.
Sue writes: Most Cherished TWIV team, I`m in sunny Etruria and had some contact with Vincent over the translation of Christian Drosten`s podcast early in the pandemic. I`m an assiduous listener of both podcasts! Infinite…
Avital writes: Hello Daniel and TWiV team! I just got my second shot of Moderna today (picture with my TWiV shirt attached). I am a single mom with a 7-year-old daughter. I don’t mind isolation,…
The Hosts of TWiV
Vincent Racaniello, Ph.D.
Dickson D.
Despommier, Ph.D.
Alan Dove, Ph.D.
Daniel Griffin, M.D.,
Ph.D., CTropMed CTH
Angela Mingarelli, DVM
Jolene Ramsey, Ph.D.