This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.
Eben writes: Dear Dr. Griffin, I am a longtime listener to COVID clinical updates and know that you have already done some episodes related to pericarditis in kids after SARS-CoV-2 infections. I was wondering if…
Mark writes: Love your podcast. I’m not in the business, just a curious “civilian” who appreciates the breadth and depth you bring to various topics. I don’t know if you take listener questions, but if…
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
Albert writes: Dear Dr. Griffin, I am returning to the US from 2 years in Mexico. I am 75 with mild hypertension, a BMI of 30, asthma and Afib. I got two shots of Sinovac…
Jeremy writes: Dear TWiV, I listened to your clear and informative discussion with Michael Worobey in TWiV 876 about his recent preprint showing the Huanan market was the epicenter of early COVID-19 cases. He explained…
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.
Colin writes: I’m a big fan of the show and have been lucky enough to have Vincent, Brianne and Alan Dove as guests on my show at various times. I’ve been a little puzzled by…
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.
The Hosts of TWiV
Vincent Racaniello, Ph.D.
Brianne Barker, Ph.D.
Rich Condit, Ph.D.
Alan Dove, Ph.D.
Daniel Griffin, M.D.,
Ph.D., CTropMed CTH
Angela Mingarelli, DVM
Jolene Ramsey, Ph.D.
Kathy Spindler, Ph.D.