TWiV 887: Bonfire of the monocytes

April 10, 2022

TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Download TWiV 887 (65 MB .mp3, 108 min)
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Intro music is by Ronald Jenkees

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3 comments on “TWiV 887: Bonfire of the monocytes

  1. H. Bradford Hawley, MD Apr 11, 2022

    A prominent feature of autopsied patients with COVID-19 is the finding of micro thrombosis. Microthrombosis is the result of membrane attack complex induced endotheliopathy which releases ultra large von Willebrand factor. SARS-CoV-2 is not found the amounts suggested by having ACE2 receptors in endothelial cells so it does not appear that the virus itself is causing endotheliopathy.. Microthrombosis of the liver causes increases in D-dimer and may also be the cause of increases in LDH mentioned in TWiV 887?

  2. Did I get this right they were looking for the Sarscov2 N protein in the monocytes.
    As the vaccines in USA only have S protein, then they could not detect N as it is not in the mix.