TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
TWiV 769: MIS-C and leaky gut
- June 17, 2021
- Tagged as: chicken egg, coronavirus, COVID-19, h3n2, influenza vaccine, leaky gut, MIS-C, pandemic, SARS-CoV-2, viral, virology, virus, viruses, zonulin
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.
TWiV 582: This little virus went to market
- January 12, 2020
- Tagged as: african swine fever virus, capsid, China, coronavirus, cryo-electron micrography, giant virus, Huanan Fish Market, influenza, influenza excess mortality, influenza like illness, influenza vaccine, pig, Swine, three dimensional virus structure, viral, virology, virus, viruses, Wuhan pneumonia, zoonosis
TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.
TWiV 581: Alimentary particles
- January 5, 2020
- Tagged as: Aedes aegypti, Aedes albopictus, antibiotic, antibody, arbovirus, blood meal, H1N1, h3n2, influenza vaccine, microbiome, mosquito, vector competence, viral, virology, virus
For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential.
TWiV 571: Piwi koalas
- October 27, 2019
- Tagged as: baculovirus, endogenous retrovirus, Flu, Flublock, Flucelvax, germline, HA, influenza, influenza vaccine, insect cell, Koala, Koala retrovirus, piRNA, transposon, viral, virology, virus, viruses
The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion.
A TWiV trio reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole.
TWiV 403: It’s not easy being vaccine
- August 21, 2016
- Tagged as: adjuvant, AS04, cold chain, efficacy, flumist, herpes zoster, influenza, influenza vaccine, IPV, LAIV, mitochondria, OPV, plant, poliovirus, shingles, thermostable, Vaccine, vaccine efficacy, viral, virology, virus, viruses, Zostavax
The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.
The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy.
TWiV 322: Postcards from the edge of the membrane
- February 1, 2015
- Tagged as: antiviral, Bourbon virus, careers in virology, crispr, dengue, H1N1, hantavirus, hepatitis C virus, herpes simplex virus, influenza vaccine, influenza virus, measles, mumps, narcolepsy, NHL, opossum, patent, peer review, serotype, sexual transmission, Smallpox, viral, virology, virus
The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.