Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Plemper
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Download TWiV 888 (65 MB .mp3, 108 min)
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Links for this episode
- Richard on TWiV 636 1:25
- Molnupiravir in ferrets (Nat Micro) 1:52
- Oral prodrug of Remdesivir in ferrets (Nat Commun) 52:13
- Letters read on TWiV 888 1:06:37
- Timestamps by Jolene. Thanks!
Weekly Picks 1:19:25
Brianne – BioRender Poster Builder
Alan – Hexbug cat toys
Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine
Listener Picks
Sue – American Visionary Art Museum
Frazer – Vaccine trial for killer elephant virus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Be assured that our current healthcare system is cleverly designed to thwart any attempts at early effective oral coronavirus antiviral agents. Only physicians and not pharmacists can prescribe these agents. Physicians will require confirmatory PCR tests and possibly office visits before prescribing antivirals and this delay will result in a delay beyond the 36 hours suggested by Dr Plemper for effective Rx. We know how this happens because it has happened for years in the treatment of influenza with oral agents.
Hello Vincent
I just got an idea I wanted to share with you. Please consider Dr Ginger Campbell to be a host on TWIN. She does the Brain Science Podcast and I learned about TWIV from her.