Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.
Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses.
Immune 53: Dendritic cell robbers
- February 21, 2022
- Tagged as: complement, dendritic cells, immune, immunology, marginal zone B cells, MHC, trogocytosis
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.
Immune 51: Teenage NINJA mice with Nikhil Joshi
- December 22, 2021
- Tagged as: central tolerance, immune, immunology, LCMV, neoantigen, NINJA mouse, T cell, thymus
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.
Immune 50: Red blood cells are immune sentinels
- November 11, 2021
- Tagged as: anemia, COVID-19, DNA, immune, immunology, innate immunity, macrophage, red blood cell, sepsis, Tlr9
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.
Immune 49: I fell in love with worms with Keke Fairfax
- October 13, 2021
- Tagged as: B cells, egg antigen, helminth, IL-4, immune, immunology, immunometabolism, macrophage, schistosomiasis
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.
Immune 46: Bats don’t STING like a bee
- July 27, 2021
- Tagged as: bat, cGAS, DNA sensing, immune, immunology, interferon, STING, virus reservoir, zoonosis
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.