Cindy talks with Shane Crotty about his teenage days driving 3 ½ hours every weekend to have his first research experience in marine biology, how that eventually led to studying how vaccines work and how…
Immune 94: The nose knows
- July 29, 2025
- Tagged as: complement, granzyme, IgA, immune, immunity, immunology, nasal immunity, nose, respiratory
The Immune team goes up the nose to discuss cytotoxic T cells activating complement through secretion of granzyme K to drive inflammatory nasal polyps and how IgA-producing B cells are made in the nose. Hosts: Vincent…
Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to…
Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the…
Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell…
From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune’s Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and…
Immune reviews how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and…
Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne…
Immune 87: When the immune system misbehaves
- January 14, 2025
- Tagged as: Allergies, allergy, antigen presentation, asthma, autoantibodies, autoimmune disease, autoimmunity, B cells, basophils, EBV, IL-33, immune, immunity, immunology, inflammation, invariant chain, Lupus, MHC class II, SLE, Systemic Lupus Erythematosus, T cells, type two inflammation, virus
Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker…
Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello, Cindy Leifer,…