TWiV 821: Public clonotype #1

October 24, 2021

A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Download TWiV 821 (60 MB .mp3, 101 min)
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Intro music is by Ronald Jenkees

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4 comments on “TWiV 821: Public clonotype #1

  1. Wayne Hamilton Oct 27, 2021

    Just a quick typo report: the running time Is more like 121 minutes.

  2. Krissy Klabacha Oct 27, 2021

    “Has anyone sampled the coelacanth for paramyxoviruses?”

    Vincent Racaniello, who just made my year

  3. I miss your living room background

  4. JJackson Oct 30, 2021

    Facinating as always. I would be most grateful if someone could explain the various pluses and minuses after a B cells , I had assumed they just refered to the presence or absence of the receptor but Vincent mentioned ,at about 42:30, that the naieve B cell would be IgG-, IgD+ which would make my assumption wrong. I have also seen CD4++ which would be what? Sorry if this is a really dumb question but it has been bugging me for a while.