A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Download TWiV 821 (60 MB .mp3, 101 min)
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Links for this episode
- Bat and rodent paramyxoviruses from Arizona (J Viral) 2:27
- Naive B cells engage SARS-CoV-2 RBD (Science Immunol) 26:06
- Vincent interviews Philip Sharp (ASM) 1:55:38
- Letters read on TWiV 821 1:56:04
- Timestamps by Jolene. Thanks!
Weekly Picks 1:29:23
Brianne – Apod: The Dolphin Head Nebula
Rich – The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants
Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories
Listener Picks
Jason – Home Assistant
Alena – VirusCraft
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Just a quick typo report: the running time Is more like 121 minutes.
“Has anyone sampled the coelacanth for paramyxoviruses?”
Vincent Racaniello, who just made my year
I miss your living room background
Facinating as always. I would be most grateful if someone could explain the various pluses and minuses after a B cells , I had assumed they just refered to the presence or absence of the receptor but Vincent mentioned ,at about 42:30, that the naieve B cell would be IgG-, IgD+ which would make my assumption wrong. I have also seen CD4++ which would be what? Sorry if this is a really dumb question but it has been bugging me for a while.