TWiV 671: Prizes, polio, and a pandemic puzzle

October 11, 2020

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: Daniel Griffin and Amy Rosenfeld

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Download TWiV 671 (102 MB .mp3, 170 min)
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Links for this episode

Weekly Science Picks 2:38:37

AmyCoronavirus : A book for children by Kate Wilson and Nia Roberts
AlanLost Prologue
RichRAPS COVID-19 vaccine tracker
VincentA Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184

Intro music is by Ronald Jenkees

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6 comments on “TWiV 671: Prizes, polio, and a pandemic puzzle

  1. Lisa Jones Oct 11, 2020

    I am grateful for all ll you do.

    Amy is a great guest/addition.

    About testing:. What about the packaging and waste? I’d love to hear Dickson and the team discuss medical and lab waste and what can be done to reduce it or use it in cogeneration power plants or ??? Where do all those gloves and dead mice and petri dishes wind up today?

  2. Really appreciated Amy’s skepticism in addition to Vincent’s grumpiness!

  3. Margie Guillot Oct 14, 2020

    The link for the book Amy recommded didn’t work.

    This is the one that did:

    The kindle version was free (today at least).


  4. Xandur Oct 16, 2020

    Apparently NIH/NIAID has continued to progress on the AFM issue. Even though Corona takes all the spotlight, they support the vaccine development against this EVD68 AFM candidate based on the polio knowledge and Vero cell platform.
    We don’t know if AFM continues to expand, but we proactively already work on potential vaccines. Did we learn from corona…..

  5. Russ Steinke Oct 16, 2020

    It would seem appropriate here to mention 3 other wonderful books highly
    recommended by Dr. Racaniello, all available through Amazon:

    “The Immortal Life of Henrietta Lacks” by Rebecca Sloot, a New York Times best-seller.
    – A well-written and researched story of human interest as well as medical history

    “Ahead of the Curve” by Shane Crotty, a biography of David Baltimore, Nobel laureate, [not to be confused with other books of the same name!]
    – A look into the life and studies of one of the most prominent researchers of our time

    “Madness and Memory: the discovery of prions”, autobiography of Stanley Prusiner, Nobel laureate

    – With some knowledge of the subject area gained from Dr. Racaniello’s Columbia lecture series and other studies in cellular biology, to me this book read like a mystery novel, with its plot unfolding page after page in dramatic fashion. Dr. Pusiner’s fascinating history of his trials and tribulations, and his eventual triumph, is highly recommended reading for all of us “armchair virologists” who follow TWIV regularly.

  6. Please leave contact information for Dr. Amy R.

    I’d like to follow her work, donate to twiv, and get an ‘Aoow my brain hurts’ T-Shirt.

    Reply to:

    Thank you.