This Week in Virology

TWiV 209: When the virus hits the fans

December 2, 2012

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more.

Click arrow to play | Download TWiV 209 (81 MB .mp3, 113 min)

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TWiV 208: The biomedical research crisis with Jon Yewdell

November 25, 2012

Hosts: Vincent Racaniello and Jon Yewdell

Vincent is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research.

Click arrow to play | Download TWiV 208 (63 MB .mp3, 87 min)

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Links for this episode:

How to succeed in science: Taking the plunge (Nat Rev Mol Cell Biol)
How to succeed in science: Making discoveries (Nat Rev Mol Cell Biol)
How to succeed in science (YouTube)
Resources for graduate students and postdocs
Science career cartoons by Alexander Dent

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TWiV 207: Silk sheets and viral infidelity

November 18, 2012

silkworm cocoon Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler

Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus.

Click arrow to play | Download TWiV 207 (76 MB .mp3, 106 min)

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Links for this episode:

Silk stabilization of antibiotics and vaccines (PNAS)
Impaired-fidelity coronavirus vaccine (Nature Medicine)
Select agent status and SARS therapies (Spoonful of Medicine)
Letters read on TWiV 207

Weekly Science Picks

Matt – Virus-associated p yramids (slide #11)
Alan – Similarities of wave behavior (YouTube)
Kathy – The glass transition
Vincent – US cattle country in uproar at virus lab plans (BBC)

Listener Pick of the Week

Ricardo – Blackawton bees and Science is for everyone (TED)
Tony – Biophilia by Bjork

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TWiV 206: Viral turducken

November 11, 2012

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Kathy Spindler

Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses.

Click the arrow above to play, or right-click to download TWiV 206 (72 MB .mp3, 100 minutes).

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Links for this episode:

TWiV 206 transcript (pdf)
Innate immunity and nuclear reprogramming (Cell)
Viruses affect cell reprogramming (The Scientist)
Cell-penetrating peptides (Trends Mol Med)
Provirophages and transpovirons (PNAS)
Organic Lake photo and map
Letters read on TWiV 206

Weekly Science Picks

Alan – Locust by Jeffery A. Lockwood
Dickson – Nikon Small World Contest 2012
Kathy – Influenza Encyclopedia
Vincent – Dengue fever sweeps India (NY Times)

Listener Pick of the Week

Allison – Fred Guterl on The Daily Show

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TWiV 205: Genetic conflict with Harmit Malik

October 28, 2012

Hosts: Vincent Racaniello and Harmit Malik

Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict.

Click the arrow above to play, or right-click to download TWiV 205 (74 MB .mp3, 103 minutes).

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Links for this episode:

Harmit on YouTube
Retroviruses and mammalian placentation (PNAS)
Paleovirology (Curr Opin Virol)
Evolution among AIM2-like receptors (J Exp Med)
Poxvirus genomic accordions (Cell)
Letters read on TWiV 205

Weekly Science Picks

Vincent – Candidates’ answers to science questions

Listener Pick of the Week

Steve – Mural of Henrietta Lacks story (alternate link)

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TWiV 204: M m m my corona

October 21, 2012

my corona Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler

Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS.

Click the arrow above to play, or right-click to download TWiV 204 (66 MB .mp3, 96 minutes).

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Links for this episode:

Novel coronavirus (virology blog one, two)
PCR assay for novel CoV (Eurosurveillance)
Isolation of novel coronavirus (NEJM)
SARS CoV now a select agent (Federal Register, pdf)
My Sharona
Pathogenic SIV infection associated with expansion of gut virome (Cell)
Letters read on TWiV 204

Weekly Science Picks

Alan – Map of the Wind
Matt – Dark Side of the Earth; Insensitive guide to thriving in your Ph.D.; Gary Vanerchuck (YouTube)
Kathy – How much does a shadow weigh? and Slinky drop answer
Vincent – A Parasite’s Parasites; All the cool kids are on arXiv

Listener Pick of the Week

Nissin – Jungle Jim (1948)

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TWiV 203: Mark Challberg, a cold room kind of guy

October 14, 2012

TWiV 200 3D phage plaque Hosts: Vincent Racaniello, Rich Condit, and Mark Challberg

Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer.

Click the arrow to play, or right-click to download TWiV 203 (69 MB .mp3, 96 min)

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Links for this episode:

TWiV 203 transcript (pdf)
Purification of vaccinia virus DNA polymerase (J Biol Chem)
Adenovirus DNA replication in vitro (PNAS)
Herpes simplex viral genes required for DNA synthesis (J Virol)
Letters read on TWiV 203

Weekly Science Picks

Rich – Mattel Hot Wheels Curiosity Rover
Vincent – Should H5N1 Moratorium End?

Listener Pick of the Week

Claudio – DIY lab equipment (Ars Technica) and DIY Bio

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TWiV 202: Huskers go viral

October 7, 2012

Hosts: Vincent Racaniello, T. Jack Morris, James Van Etten, and Charles Wood

Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi’s sarcoma herpesvirus.

Click arrow to play, or right-click to download TWiV 202 (52 MB .mp3, 72 min)

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Links for this episode:

Weekly Science Picks

Charles – Rhabdovirus associated with hemorrhagic fever (PLoS Path)
Vincent – Bacteriophage graffiti (jpg)

Listener Pick of the Week

Bob – Remembering Penny Pinneo
Janet – Penn and Teller on vaccinations (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv.

TWiV 201: Rabid about viruses

September 30, 2012

World Rabies Day Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Kathy Spindler

Vincent, Alan, Rich, Dickson, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more.

Click the arrow above to play, or right-click to download TWiV 201 (90 MB .mp3, 125 minutes).

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Weekly Science Picks

Alan – Wallace Online
Rich – World Rabies Day
Kathy – Yo-yos in space
Dickson – The Art in Science
Vincent – The Podcasters Studio

Listener Pick of the Week

Wink – DuckDuckGo
Josh – Introduction to Solid State Chemistry

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv.

TWiV 200: Threading the NEIDL

September 23, 2012

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley

Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.

Click the arrow above to play, or right-click to download TWiV 200 (72 MB .mp3, 100 minutes).

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Weekly Science Picks

Alan – Dance your Ph.D.
Rich – Angel of Death by Gareth Williams
Vincent – Why herpesvirus is good for you (Virgin lab)

Listener Pick of the Week

Luis – VBORNET maps

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TWiV Team in BSL4 suits

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