This Week in Virology - Part 87

TWiV 397: Trial by Error

July 10, 2016

Host: Vincent Racaniello

Guest: David Tuller

Vincent speaks with David Tuller about flaws in the U.K’s $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.

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Links for this episode

Science and journalism (TWiV 111)
Chronic fatigue syndrome and the CDC (virology blog)
PACE trial (Lancet)
Trial by error part one, two, three (virology blog)
PACE economics analysis (PLoS One)
All articles by David Tuller at virology blog
Valerie Eliot Smith’s blog
Karina Hansen, prisioner of Denmark

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to [email protected]

TWiV 396: Influenza viruses with Peter Palese

July 3, 2016

Host: Vincent Racaniello

Guest: Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

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Links for this episode

Palese Laboratory
Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem)
DNAse in cytoplasmic DNA virus (Virology)
Inhibitor of influenza virus neuraminidase (Virology)
Influenza neuraminidase defective mutants (Virology)
Swine influenza virus of 1976 RNA pattern (Nature)
1977 influenza H1N1 similar to 1950s strains (Nature)
H5N1 influenza: Facts, not fear (PNAS)
Influenza HA stalk immunity in ferrets (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to [email protected]

TWiV 395: The cancer thief

June 26, 2016

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Stephen J. Russell

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy – using viruses to treat cancers.

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Links for this episode

Hokies go viral (TWiV 285)
MV NIS de Myelo (TWiV 298)
Remission of disseminated myeloma after MV treatment (Mayo Clin Proc)
miRNA detargeting (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Kathy – Can you explain your science in 30 seconds? and How Far Can We Go?
Rich – Small asteroid Earth’s companion
Vincent – The Gene by Siddhartha Mukherjee

Listener Picks

Dylan – Microsculpture by Levon Biss (website)

Send your virology questions and comments to [email protected]

Photo by Matt Evans

Photo by Vincent Racaniello

TWiV 394: Cards in a hand

June 18, 2016

Hosts: Vincent Racaniello and Alan Dove

Guest: Erica Ollmann Saphire

Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

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Links for this episode

Structure of antibodies bound to Ebola virus glycoprotein (PNAS)
Structure of cross-reactive filovirus antibody (Cell)
Multiple functions of Ebola virus VP40 protein (Cell)
Letters read on TWiV 394

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan – Slime Lapse
Vincent – Virus Watch

Listener Picks

Patricia – NECSS, People Behind the Science, The Life Scientific
Peter – Iron Lung on eBay

Send your virology questions and comments to [email protected]

TWiV 393: Lovers and livers

June 12, 2016

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

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Links for this episode

Late sexual transmission of Zika virus (Lancet) 8:10
Zika virus disease in US (CDC) 11:30
Zika virus lab accident (ABC News) 25:30
Mosquito eradication (virology blog) 20:35
Florida mosquito control (TWiV 111) 19:35
How tequila mosquito (TWiV 178) 23:55
SEC14L2 allows HCV replication in cell culture (Nature) 27:15
Lipid peroxidation (Wikipedia) 39:40
HCV replicase regulated by lipid peroxidation (Nat Med) 41:15
Letters read on TWiV 393 52:00

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 48:40

Also brought to you by ASV 2016 5040

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:23:25

Alan – All About That Space
Rich – The Expanse by James S.A. Corey (SyFy or books)
Kathy – Five Pivotal Paragraphs in a Paper
Vincent – Agar Art Contest Winners

Listener Picks

Ted – Marshall Niremberg charts

Send your virology questions and comments to [email protected]

TWiV 392: Zika virus!

June 5, 2016

Host: Vincent Racaniello

Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice

Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.

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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to [email protected]

TWiV 391: Whiter reefs, fresh breath

May 29, 2016

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: David Pride and Forest Rohwer

If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you’ll also understand why mucus is cool.

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Links for this episode

Lytic to temperate switching of viral communities (Nature)
Viromes in ancestral holobiont Hydra (PLoS One)
Phage in human oral cavity (J Oral Micro)
Human oral viruses are personal, consistent, gender specific (ISME)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan – Vax Pack Hero
Rich – Helicopter autorotation
Vincent – Life in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa

Listener Picks

Matt – Experiment.com

Send your virology questions and comments to [email protected]

TWiV 390: Building a better mosquito trap

May 22, 2016

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Ethan Jackson and Jonathan Carlson

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.

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Links for this episode

Project Premonition 8:20
Premonition feasibility study in Grenada 37:00
Zika virus causes microcephaly in mice (Cell Stem Cell) 1:33:25
Brazilian Zika virus causes defects in experimental models (Nature) 1:38:15
Zika virus causes placental damage and fetal demise in mice (Cell) 1:45:00
Letters read on TWiV 390 1:09:05

Image: An early prototype of the mosquito trap (image credit).

Timestamps by Jennifer. Thanks!

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:02:00

Also brought to you by ASV 2016 1:56:00

Weekly Science Picks 1:57:25

Dickson – Germany nearly reached 100% renewable power
Alan – Vertical City documentary and Lumino City game
Rich – Errol Morris: ‘Demon in the Freezer’
Kathy – Entropic Time YouTube by A Capella Science (watch “the making of”)
Vincent – Agar Art contest finalists

Listener Picks

Jennie – SciFi reading (scroll down)

Send your virology questions and comments to [email protected]

TWiV 389: Alphabet hepatitis with Stan Lemon

May 15, 2016

Host: Vincent Racaniello

Guest: Stan Lemon

Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.

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Download TWiV 389 (53 MB .mp3, 73 min)
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Links for this episode

Live in Edmonton, Eh? (TWiV 235)
Replication of EBV in epithelial cells (Nature)
Returning to Carolina after 14 years
Evolutionary origins of hepatitis A virus (TWiV 265)
cre in rhinovirus genome (RNA)
Naked viruses that aren’t always naked (Ann Rev Virol)
miR-122 and hepatitis C virus RNA (Cell Host Micr)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to [email protected]

TWiV 388: What could possibly go wrong?

May 8, 2016

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.

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Links for this episode

biorXiv preprint server 8:55
Please review Vaccines and Your Child 37:00
Structure of antibody bound to Zika virus E protein (Cell Host Microbe) 50:45
Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe) 58:25
Zimmer on Wolbachia and Zika virus (NY Times) 59:45
Fauci on Zika virus vaccine (Science) 1:13:50
Carpageddon (The Conversation) 1:15:30
Letters read on TWiV 388 5:40

Timestamps by Jennifer. Thanks!

Image: A single molecule of the Zika virus E glycoprotein (red) bound to a broadly neutralizing antibody (green). The fusion loop on the E protein, which is recognized by the antibody, is shown in yellow.

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 48:40

Also brought to you by ASV 2016

Weekly Science Picks 1:23:55

Dickson – EarthEnv
Alan – Research funding by lottery
Kathy – Eugenia Cheng Math and Baking
Vincent – Zika Diaries

Listener Picks

Stephen – Virus trading cards
William – Virus trading cards
Norma+Maurice – Virus trading cards
Tom – Virus trading cards

Send your virology questions and comments to [email protected]

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