TWiV 951: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Intro music is by Ronald Jenkees

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TWiV 950: Prion diseases with Richard Knight

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Intro music is by Ronald Jenkees

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TWiV 949: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Intro music is by Ronald Jenkees

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TWiV 948: Breathless with David Quammen

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Weekly Picks 1:34:15

David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich – “Elementary” TV series
Vincent – Stop passing the buck on intro science

Listener Pick

Rich – Consensus

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 947: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Intro music is by Ronald Jenkees

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TWiV 946: Poo versus flu

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker

Guest: Angela Mingarelli

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Weekly Picks 1:23:20

Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich – Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 945: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 944: Hacking through Borneo with Kathryn Hanley

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.

Hosts: Vincent Racaniello, Rich Condit,  and Kathy Spindler

Guest: Kathryn Hanley

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Weekly Picks 1:33:11

Kathy – Car Talk Puzzler Archive
Rich – The Molecular Biologist Who Exposed the Soviet Union”  by Sean B. Carroll
Vincent – NYU Chemistry prof fired because his course was too difficult

Listener Pick

Jack – The Everything Virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 943: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Public Health with Laurie Garrett: Wastewater Testing

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions and comments to [email protected]

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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