TWiV 956: A domesticated viral envelope with Cedric Feschotte and John Anthony Frank

November 20, 2022

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Cedric Feschotte and John Anthony Frank

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Download TWiV 954 (63 MB .mp3, 104 min)
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  • Support MicrobeTV with a Spike t-shirt ( with promo code MicrobeTV 6:41
  • Cedric on TWiV 935 1:24
  • Antiviral retroviral protein (Science) 8:24
  • Stealing genes, facing consequences (Science) 47:37
  • Letters read on TWiV 956 1:04:42
  • Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees

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2 comments on “TWiV 956: A domesticated viral envelope with Cedric Feschotte and John Anthony Frank

  1. Dr. Michael R. Hodges MD Nov 21, 2022

    Sorry this is not a reply to last week’s episode. Rather, just wanted you to be aware of the Lancet’s report on the CDC pandemic “findings” and CDC “changes” Lancet 2022 US CDC begins agency-wide changes after pandemic failures

    Panel: Key findings and recommendations from the CDC review
    It takes too long for the CDC to publish its data and science for
    decision making
    • Create an online mechanism for pre-publication delivery of
    • Expedite the review or approval process for scientific
    publications and data (including laboratory data) to match the
    needs of the emergency
    The agency’s turnover of staff during the COVID-19 response
    created gaps and other challenges for partners
    • Increase the number of CDC leaders trained and ready to deploy
    to a response
    • Require a minimum of 6-month rotation for leadership positions
    on the response; build a redundancy model of emergency
    staffing (ie, backup or co-lead staff in all key positions) to prevent
    response burnout and assure continuity in operations
    The agency’s guidance documents are confusing and
    overwhelming, and the website is not easy to navigate
    • Produce plain-language, easy-to-understand implementation
    guidance documents that apply over multiple settings; reduce
    the number and length of guidance documents; include a brief
    scientific rationale or background in the implementation
    guidance with a referenced or accompanying Morbidity and
    Mortality Weekly Report, Science Brief, as necessary
    • Restructure the agency web site and digital communication
    platforms to eliminate unnecessary content and focus on key
    target audiences with a primary emphasis on the public
    COVID-19 uncovered the need for flexibilities that do not exist
    today at the CDC
    • Establish new authorities that will allow the CDC to be more
    nimble and work faster, such as public health and regulatory
    authorities mandating data collection from local jurisdictions,
    and human resource authorities with authority to hire faster,
    and ensure competitive salaries to recruit and retain for hardto-
    fill positions like data scientists

  2. In response to Lisa from Austin’s letter, this Stanford website might be helpful: A LOW SCORE IS BETTER! You’ll have to look for what all the abbreviations mean; the information is there though, I share Lisa’s view that a cocktail of two highly effective monoclonal antibodies,(which may need to be from different companies) is likely to be more escape-proof.