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Tag: evolution

  • Episode

TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

  • April 4, 2020
  • Tagged as: CoV, COVID-19, evolution, genetic epidemiology, genome evolution, natural selection, SARS-CoV-2, viral, virology, virus, viruses

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

6 Replies
  • Episode

TWiEVO 52: Virus evolution by land and by sea and by CoV

  • February 26, 2020
  • Tagged as: ACE2, bat, coronavirus, CoV, evolution, pangolin, positive selection, receptor binding domain, SARS-CoV-2, spike glycoprotein, virus, viruses, zoonosis

Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

5 Replies
  • Episode

TWiEVO 51: The starting point paradox

  • January 22, 2020
  • Tagged as: abiotic amino acids, abiotic synthesis, coacervate, evolution, evolve, natural selection, origin of life, ornithine, primordial amino acids, protein evolution

Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.

2 Replies
  • Episode

TWiEVO 50: I’m dreaming of a Y chromosome

  • December 23, 2019
  • Tagged as: 3-spined stickleback fish, evolution, gene duplication, genome assembly, natural selection, sex chromosome, sex determination, Y chromosome

Nels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish.

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  • Episode

TWiEVO 49: A giant podcast on giant viruses

  • November 29, 2019
  • Tagged as: ecology, evolution, giant virus, horizontal gene transfer, natural selection, NCLDV, Nucleocytoplasmic large DNA containing viruses, phycodnavirus, Ringberg, viral, virology, virophage, virus, viruses

Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany.

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  • Episode

TWiEVO 48: Flipping out with choanos on caffeine

  • October 30, 2019
  • Tagged as: actomyosin, choanoflagellate, contraction, evolution, light regulated contraction, multicellularity, natural selection, phosphodiesterase, rhodopsin

Nels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior.

1 Reply
  • Episode

TWiEVO 47: On the origin of beer species

  • September 19, 2019
  • Tagged as: admixture, ale, allele, beer yeast, evolution, fermentation, lager, natural selection, polyploidy, recombination, Saccharomyces cerevisiae, wine

Nels and Vincent trace the origins of Saccharomyces cerevisiae strains used to make beer, and find that ales and lagers are made with yeasts that were derived from those used to make European grape wine and Asian rice wine.

1 Reply
  • Episode

TWiEVO 46: Can an old tumor teach us new tricks?

  • August 31, 2019
  • Tagged as: APOBEC, cancer lineage, canine transmissible tumor, evolution, mutational signature, natural selection, somatic evolution

Nels and Vincent analyze the genomes of canine transmissible tumors to provide insight into the worldwide spread of the disease from its origin in a single dog 4000-8500 years ago, and its diversity, mutation, and evolution.

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  • Episode

TWiEVO 45: Microbial secrets of mouse-ear cress

  • July 29, 2019
  • Tagged as: agricultural disease, agriculture, Arabidopsis thaliana, evolution, microbiome, monoculture, OTU, plant pathogen, Pseudomonas

At ASM Microbe in San Francisco, Nels and Vincent meet up with Talia Karasov who reveals that in contrast to agriculture, wild plants are colonized by multiple lineages of pathogenic bacteria.

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  • Episode

TWiEVO 44: The enemy of my enemy is my phage

  • June 27, 2019
  • Tagged as: antimicrobial efflux pump, antimicrobial resistance, evolution, Mycobacterium, phage therapy, Pseudomonas, viral, virus, virus entry, viruses

At ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria.

4 Replies
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The Hosts of TWiEVO

Nels Elde, Ph.D.


Vincent Racaniello, Ph.D.


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