TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

April 4, 2020
nextstrain.org

Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.

Hosts: Nels Elde and Vincent Racaniello

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6 comments on “TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

  1. VIKTOR MALAKHOV Apr 4, 2020

    Hi Vincent and Nels,
    thanks for your great podcast.

    I have a question regarding your estimates of coronavirus mutation rate. You sort of downgraded that on the podcast (rightfully so, considering how media react to those). but while the nextstrain.org gives an 24.75 subs/year for ncov, it also contains dataset for other viruses. So for flu they have 3.53e-3/site/year, which matches well with the literature I think. However, when comparing apples to apples it is 8e-4 for ncov, or roughly 4 times less the mutation rate of the influenza virus.

    While this is definitely smaller, but still pretty much comparable, don’t you think?

    thanks again for your great podcast, it’s an essential part of my ‘shelter in place’ routine these days,
    Victor,
    Moscow, Russia
    a student of Vincent online courses since 2014

  2. RT Monson Apr 4, 2020

    What a pleasant conversation about the science of CoV-2 and beyond. The measured and knowledgeable voice of Dr. Elde through the welcome nudges of Vincent provides a welcome window into our current context and future challenge opportunities.
    Thank you for this conversation that welcomes laypersons into it. You both are so well-spoken. Impressive!
    Thank you, Nels, for your depth of knowledge, experience, and research in this important SCIENCE!
    RT

  3. noob here, divergence number in nextstrain means?
    i.e.: “Divergence: 7.962”

    • When tree is changed from time to divergence it gets higher from left to right.

  4. Teresa Liddell Shepherd Apr 5, 2020

    Could it be possible to have a transcript for those who can’t hear please?

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