Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.
TWiV 699: Arboviruses at ASTMH
- December 27, 2020
- Tagged as: arbovirus, bridge vector, flavivirus, mosquito, Rift Valley fever, RNAi, viral, virology, virus, viruses
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.
TWiV 633: Singapore viral
- June 30, 2020
- Tagged as: dengue virus, DukeNUS, flavivirus, interferon, rig-i, RNA sensor, viral, virology, virus, viruses, yellow fever virus
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.
TWiV 605: READDI for the next pandemic
- April 23, 2020
- Tagged as: alphavirus, antiviral drug, Chikungunya virus, COVID-19, dengue virus, flavivirus, pandemic, READDI, SARS-CoV-2, viral, virology, virus, viruses, Zika virus
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.
Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization.
TWiV 547: Upstate virology
- May 12, 2019
- Tagged as: arbovirus, DDX68, epitranscriptome, flavivirus, hepatitis C virus, mosquito vector, viral, virology, virus, viruses, west nile virus, Zika virus
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses.
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.
TWiV 527: City mouse, country mouse
- December 30, 2018
- Tagged as: deer mouse, enteric nervous system, flavivirus, hantavirus, hantavirus pulmonary syndrome, IBS, inflammatory bowel syndrome, intestinal dysmotility syndrome, neurotropic, outbreak, Peromyscus maniculatus, sin nombre virus, viral, virology, virus, viruses, west nile virus, zoonosis
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.
In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.
TWiV 473: Assessing a risk and infecting you twice
- December 24, 2017
- Tagged as: antibody dependent enhancement, dengue, DHF/DSS, Fc receptor, flavivirus, fucosylation, viral, virology, virus, viruses
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.
Inside a BSL-4
