Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Eva Harris and Janet Smith
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Download TWiV 725 (72 MB .mp3, 119 min)
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Links for this episode
- Eva Harris on TWiV 228 1:28
- Zika virus in Nicaragua (virology blog) 2:26
- How an antibody block NS1-mediated endothelial dysfunction (Science) 13:13
- Protein Data Bank NS1 complex structures (one, two, three)
- Broadly protective antibody against NS1 (Science) 59:32
- Letters read on TWiV 725 1:18:42
- Timestamps by Jolene. Thanks!
Weekly Picks 1:44:07
Alan – Science Photographer of the Year Awards
Rich – Bar Keeper’s Friend
Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
Vincent – COVID-19 dataset
Listener Picks
Matthew – Remembering the colleagues we lost to COVID-19
Lori – Iceberger
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
User picks?
NS1 Protein data bank link
https://www.rcsb.org/3d-view/5K6K/1?preset=symmetry&sele=0
Seems like the audio is for episode 723 instead of 725 where it’s just the link, in the box with the audio player, that downlink icon results in 725 downloading. Not a big deal, just solved the weird mystery of why my audio player seemed to be unable to play 725 and wanted to play 723, problem solved.
The enthusiasm here is infectious! And with good reason- a wonderful demonstration of the sheer individual stubborness needed when attempting to see and understand things outside of our normal perceptions and the vital source of support for that effort coming from a collaborative network, even when at a distance.
Very, very rewarding work and the happiness that comes from it is shared here with us all, (Thankyou to TWiV for making this engagement possible) and hopefully with the NS1 antibodies happiness for very many under-attended sufferers woldwide.
The reference in passing to SARS CoV 2 mechanisms is intriguing…hopefully we will hear more on this in the future.
Can we have a TWiV on the interaction of vaccination with post-infectious outcomes WRT increasing reports of a subset of Long Covid patients getting relief from their symptoms (hopefully not including the phrase ‘placebo effect’!)