Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates.
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.
The Hosts of TWiV
Vincent Racaniello, Ph.D.
Brianne Barker, Ph.D.
Rich Condit, Ph.D.
Dickson D.
Despommier, Ph.D.
Alan Dove, Ph.D.
Daniel Griffin, M.D.,
Ph.D., CTropMed CTH
Angela Mingarelli, DVM
Jolene Ramsey, Ph.D.
Kathy Spindler, Ph.D.