Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Shane Crotty
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Links for this episode
- ASV Vaccine Town Halls 2:18
- SARS-CoV-2 immune memory 8 months post-infection (Science) 5:24
- SARS-CoV-2 T cell epitopes (Cell Host Microbe) 37:23
- Letters read on TWiV 802 1:08:04
- Timestamps by Jolene. Thanks!
Weekly Picks 1:28:15
Brianne – How the cat gets its stripes
Kathy – Kurzgesagt on Giruses (giant viruses) and beautiful APOD
Rich – The 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle
Vincent – Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period
Listener Picks
Debby – River Runner
Lin – Your Vaccinated Immune System Is Ready for Breakthroughs
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Thanks for these terrific shows. Looking at Shane Crotty’s slides I have a question. Do you guys think it might be useful to think of COVID-19 as 2 distinct illnesses, an upper respiratory (fast) and a lower respiratory (slow) disease? Then we could say that vaccination continues to prevent the lower respiratory disease very well, while prevention of the upper respiratory disease is good but not great and probably waning some with time? It has been so confusing and even misleading to count all infections in vaccinated people as ‘breakthroughs’.
Also, thanks Rich (I think it was Rich) for saying a few TWiV’s ago, look, everyone is going to encounter this virus, and you need to decide whether to do that vaccinated or unvaccinated. At least that’s how I heard it! This clear message has been really eye-opening to people I talk to in my work.