Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.
The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research.
Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more.