TWiV 318: Last year in virology

Ebola virus cookieHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.

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Ten virology stories of 2014

  • Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283)
  • Directional uncoating of rhinovirus RNA (TWiV 267)
  • Pandemic pathogen controversy (TWiV 287)
  • Viral evolution (TWiV 275)
  • Borna virus inhibition by endogenous DNA (TWiV 303)
  • MERS-CoV in dromedary camels (TWiV special, TWiV 287)
  • Oncolytic measles virus (TWiV 298)
  • Amazing norovirus findings (TWiV 312 and 313)
  • Toxin delivery to aphids (TWiV 272)
  • The Salk Legacy (TWiV 281)

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Weekly Science Picks

Alan – Mystery photos from CERN
Rich – Adam E. Cohen: Bringing bioelectricity to light
Kathy – Wired’s top microbe stories of 2014
Dickson – Mouse joke
Vincent – The Science of Epidemics (Time Inc Special)

Listener Pick of the Week

Neva – Sir Bacteriophage
Sagi – An unboring polio documentary

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TWiV 317: Brazil goes viral

Host: Vincent Racaniello

Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa

On his second trip to Brazil, Vincent joins Eurico to speak with four young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.



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Photos of my trip are at facebook.com/thisweekinvirology

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TWiV 316: The enemy of my enemy is not my friend

Th17 cellsHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contributes to alphavirus pathogenesis.

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Weekly Science Picks

Alan – It came from the pond
Rich – Wanderers
Kathy – The Sense of Style by Steven Pinker
Vincent – Life in Our Phage World

Listener Pick of the Week

Fernando – Reality based?

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TWiV 315: Must be something in the water

Sea star wasting diseaseHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss the association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.

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Weekly Science Picks

Alan – ReelLife Science 2014 Winners
Rich – The Martian by Andy Weir
Kathy – Dance Your Ph.D. Winner
Vincent – Time Person of the Year 2014 – The Ebola Fighters

Listener Pick of the Week

Ricardo – MiniPCR
Eli – Let’s outsmart Ebola together AND The Ebola virus explained

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TWiV 314: Einstein goes viral

Host: Vincent Racaniello

Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.



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Albert Einstein College of Medicine

TWiV 313: With viruses like these, who needs enemas?

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.



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Weekly Science Picks

Alan – Retrocomputing
Rich – Where is Rosetta?
Vincent – Antares rocket explosion

Listener Pick of the Week

Simon – Relatively Prime
Mark – Giant Microbes

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intestinal villi

TWiV 312: She sells B cells

B cellHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.

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This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai.

Links for this episode

Weekly Science Picks

Alan – How Ebola airlifts work
Kathy – Fred Murphy’s Foundations of Virology
Rich – Pendulum wave
Dickson – Young Dipterists
Vincent – Microbes After Hours: Ebola and TWiV iPhone 6 case

Listener Pick of the Week

Alane – Health Map
Todd – Formaldehyde in vaccines

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv

TWiV 311: Bulldogs go viral

TWiV 311Host: Vincent Racaniello

Guests: Zhen Fu and Biao He

Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.



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TWiV 310: From bacteriophage to retroviruses with Ann Skalka

Hosts: Vincent Racaniello and Glenn Rall

Guest: Ann Skalka

Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.



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Download TWiV 310 (43 MB .mp3, 59 min)
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TWiV 310

TWiV 309: Ebola email

Firestone - EbolaHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.

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Download TWiV 309 (86 MB .mp3, 119 min)
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This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai.

Links for this episode

Weekly Science Picks

Alan – CDC Influenza activity weekly maps
Kathy – Going Deep with David Rees
Rich – Virology Special Issue: Giant Viruses
Dickson – Nikon Small World Winners
Vincent – TWiM #90 and Republicans are not scientists

Listener Pick of the Week

Paul – Tricks and Tools of Great Scientists
Yegor – Hardcore History
Amanda – Vaccine ingredients; Anti-vaxers damage; Minds of anti-vaxers

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Jolene Ramsey, Ph.D.


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