From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.

Host: Vincent Racaniello and Kathy Spindler

Guests: Tuli MukhopadhyayJohn Patton, and Adam Zlotnick

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Intro music is by Ronald Jenkees.

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APOBEC3H with dsRNATheodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

Guest: Theodora Hatziioannou

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Theodora – To Kill A Mockingbird by Harper Lee
Kathy
– 25 MILLION Orbeez in a pool
DicksonFluid Dynamics of Paint
RichThe Hitchhiker’s Guide to the Galaxy by Douglas Adams
Alan30 days at sea: timelapse
Vincent – TWiEVO 24 and Every Time Zone

Listener Picks

FernandoLego Women of NASA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.

Host: Vincent Racaniello

Guests: Katya Heldwein and Sean Whelan

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Download TWiV 464 (53 MB .mp3, 88 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Alan's aerial virusThe TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

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Download TWiV 463 (63 MB .mp3, 104 min)
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Links for this episode

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – When biospheres collide
DicksonBlame 10 rivers for ocean plastic
AlanFarming in The Netherlands
Vincent – Meet the Microbiologist

Listener Picks

JayOmegaTau podcast
Trudy – Arrowsmith by Sinclair Lewis
Mark – iOS app Human Anatomy Atlas and Master in Business podcast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

David TullerDavid Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Hosts: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Phil SharpVincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.

Hosts: Vincent Racaniello

Guest: Phillip A. Sharp

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Download TWiV 462 (24 MB .mp3, 39 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

neural circuit tracingThe TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Brianne Barker

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Download TWiV 461 (79 MB .mp3, 127 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy –Best eclipse video (to date) and solargraph
DicksonPhotos by Will Eades
BriannePale Rider by Laura Spinney
Rich – “Supergenes” Drive Evolution
Vincent –Anatomy of a Moral Panic

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.

Host: Vincent Racaniello

Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss

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Download TWiV 460 (56 MB .mp3, 93 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Saturn's virusThe TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 459 (63 MB .mp3, 105 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks 1:23:11

Kathy – Cassini photos
DicksonCaliber Biotherapeutics
AlanGrav
RichGoogle street view of the International Space Station.  (article)
Vincent – the bioinformatics chat

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

subgenomic flavivirus RNAThe TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 458 (72 MB .mp3, 119 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – Antibody validation Editorial Asilomar meeting report
DicksonDespommierphotoart.com
AlanNOAA Hurricane Hunters
Rich – Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent – Goodnight Lab by Chris Ferrie

Listener Picks

Pete – Change Agent by Daniel Suarez
Paul
Pasteur’s Gambit by Stephen Dando-Collins
Maureen – Discovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]