TWiV 685: Pandemicky

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:40:35

Brianne – Types of Scientists Coloring Book
Kathy – South Pole video
Rich – Steve Jobs by Walter Isaacson
Vincent – Screenology (I interviewed Deb Sklut here)

Listener Pick

Mona – Ad5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

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TWiV 684: Persistence of SARS-CoV-2 immune memory

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Shane Crotty

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Weekly Science Picks 2:44:51

Dickson – Benoit Mandlebrot’s 96 birthday
Brianne – #BlackinImmunoWeek
Rich – GoISSWatch ISS Tracking; Spot The Station (NASA)
Vincent – Microbes Rule

Listener Pick

Agda – Sandwalk

Intro music is by Ronald Jenkees

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TWiV 683: Two COVID-19 mRNA vaccines

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:43:25

Brianne – Picture a Scientist
Kathy – Colors of the Moon and Word that hasn’t changed
Rich – NASA YouTube channel
Vincent – Laura Splan science art

Listener Pick

Mona – Ad5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 682: Kate Rubins from the International Space Station

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.

Hosts: Vincent Racaniello and Rich Condit

Guest: Kate Rubins

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Intro music is by Ronald Jenkees

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TWiV 681: Crowley, coats, and cross-reactive antibodies

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Kathleen A. Crowley

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Weekly Science Picks 2:33:04

Dickson – OSIRIS-REx | NASA
Brianne – Virtual Science Museum Tours
Alan – Ring Fit Adventure
Rich – BUGSS Baltimore Underground Science Space
Vincent – Trilobite glassworks

Listener Pick

Gina and Joe – COVID Fan Tutte

Intro music is by Ronald Jenkees

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TWiV 680: Long-term COVID and ME/CFS

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guests: Mady Hornig, Fiona Lowenstein, and David Tuller

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Intro music is by Ronald Jenkees

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TWiV 679: Mink, mutation, and myocytes

Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Amy Rosenfeld

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Weekly Science Picks 2:14:46

Dickson – CNN News
Amy – I voted and Grace for President
Alan – The Story of More by Hope Jahren
Rich – OSIRIS-REx and 101955 Bennu
Vincent – The Vexed Muddler

Intro music is by Ronald Jenkees

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TWiV 678: Fishing for viruses with Nels Elde

Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Nels Elde

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Weekly Science Picks 58:37, 1:42:57

Kathy –  Why art is important and Tagging an asteroid
Rich – Vendee Globe
Vincent – PrePubMed

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 677: Does antibody really know what time it is?

Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Weekly Science Picks 2:25:45

Dickson – Comedy Wildlife Photography
Brianne – Ed Yong – Science reporting during a pandemic
Alan – Tree Story by Valerie Trouet
Rich – Vaccine Investigation and Online Information Network
Vincent – Wearing is Caring

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 676: Tragic gene flow from Neanderthals

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Weekly Science Picks 1:47:32

Brianne – Kids Meet a Virologist
Kathy –  Harvard glass marine invertebrates 3D online
Rich – Chernobyl fungi
Vincent – Artologica

Listener Pick

Justin – Totally Under Control

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


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