In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.

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Download TWiV 865 (58 MB .mp3, 48 min)
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Links for this episode

• Children and COVID state data (AAP) 5:14
• Human challenge study (Res Sq) 13:26
• Effectiveness of mask use (MMWR) 15:31
• Omicron boost in macaques (bioRxiv) 23:55
• Mucosal vaccine candidate (Cell) 25:47
• Long-term cardiovascular outcomes (Nat Med) 31:40
• Global vaccine perceptions (PLoSNTD) 35:30
• Letters read on TWiV 865 40:15
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC.

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Download TWiV 862 (23 MB .mp3, 38 min)
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Links for this episode

• Omicron severity challenges (NEJM) 3:00
• Children and COVID data (AAP) 6:17
• Vaccine EUA for under 5 year olds (Pfizer) 7:24
• B cell boot camp (Immune 52) 9:08
• Soft drink and LFA false positives (medRxiv) 12:41
• EUA application for Novavax vaccine (Novavax) 15:20
• Childhood experiences and vaccine hesitancy (BMJ Open) 15:58
• Fourth vaccine dose in Israel (medRxiv) 18:30
• Antibodies and antivirals vs Omicron (NEJM) 22:42
• Paxlovid and Omicron (Pfizer) 23:41
• Multiple factors and PASC (Cell) 26:14
• Internship at Parasites Without Borders (pdf) 30:08
• Letters read on TWiV 862 30:21
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Nels Elde

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Download TWiV 861 (69 MB .mp3, 114 min)
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Links for this episode

• Vaccine Town Hall (ASV)
• Columbia University BSL-3 Manager position 3:27
• Did Omicron come from mice? (J Genet Genomics) 8:27
• Persistent SARS-CoV-2 infection (SSRN) 53:46
• Letters read on TWiV 861 1:20:16
• Timestamps by Jolene. Thanks!

Weekly Picks 1:39:04

Brianne – Groundhogs Emerge From the Scientific Shadows
Kathy – Zig-zag Coast Guard search pattern
Rich – Moon Phases 2022 (Lunar Reconnaissance Orbiter)
Vincent – Kevin Cowtan’s Book of Fourier and Live Fourier Transformation
Nels – Biology versus bias

Listener Picks

Dusty – Fighting bias in space

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Download TWiV 857 (76 MB .mp3, 126 min)
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Links for this episode

• Jon Yewdell on TWiV 208, 467, 597, 620 2:10
• Letters read on TWiV 857 1:34:34
• Timestamps by Jolene. Thanks!

Weekly Picks 1:22:00, 1:26:16

Jon – The Premonition by Michael Lewis
Dickson – Nature photographer of the year 2021
Brianne – Should BioBank Volunteers Be Warned About Mutations?
Rich – Czech singer Hanka Horká dies after intentionally getting infected by the coronavirus and Dena Dietrich Dies at 91
Vincent – Cuore di Cioccolato

Listener Picks

Bronwen – Schools must stay open
John – Pandemic humor

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic.

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Download TWiV 856 (58 MB .mp3, 48 min)
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Links for this episode

• COVID-19 in South Africa (pdf) 4:09
• Ancestral T cells recognize Omicron (Nat Med) 11:36
• Booster effectiveness against COVID-19, England (Nat Med) 14:52
• Cases and hospitalization by vaccination status (MMWR) 17:48
• Infection and vaccination in pregnant women, Scotland (Nat Med) 24:43
• Early Remdesivir to prevent progression to severe disease (NEJM) 32:33
• Management of hospitalized adults (NIH) 28:00
• Tocilizumab in hospitalized patients (Resp Care) 36:19
• Vaccination and long COVID in Israel (medRxiv) 38:01
• Pandemic true death toll (Nature) 41:37
• Internship at Parasites Without Borders (pdf) 42:40
• Letters read on TWiV 856 43:12
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]