TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Download TWiV 860 (76 MB .mp3, 126 min)
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Links for this episode
- Vaccine Town Hall (ASV) 1:55
- Columbia University BSL-3 Manager position 2:14
- RNA modifications suppress innate recognition (Immunity) 4:08
- Critical contribution of pseudouridine (Front Cell Dev Biol) 34:49
- Rich Condit reminisces (YouTube) 10:26
- Letters read on TWiV 860 43:49
- Timestamps by Jolene. Thanks!
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Kathy – How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral
Rich – Fermi paradox
Vincent – Racism not Race by Joe Graves
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Intro music is by Ronald Jenkees
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