TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade.
TWiV 791: A mad virologists’ T party
- August 8, 2021
- Tagged as: COVID-19, deer, mRNA vaccine, neutralizing antibody, pandemic, rhesus macaque, SARS-CoV-2, t cells, viral, virology, virus, viruses
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.
TWiV 754: Tuesday two: SARS-CoV-2 and TLR2
- May 13, 2021
- Tagged as: coronavirus, COVID-19, cytokine storm, inflammatory cytokine, mRNA vaccine, pandemic, SARS-CoV-2, TLR2, viral, virology, virus, viruses
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.
TWiV 715: Fauci ouchy
- February 4, 2021
- Tagged as: cathepsin, coronavirus, COVID-19, hydroxychloroquine, mRNA vaccine, pandemic, Pfizer, SARS-CoV-2, spike cleavage, Tmprss2, viral, virology, virus, viruses
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.
TWiV 706: Do as Dr. Fauci says
- January 14, 2021
- Tagged as: coronavirus, COVID-19, mRNA vaccine, pandemic, SARS-CoV-2, virus, viruses
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.
TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin
- December 26, 2020
- Tagged as: coronavirus, COVID-19, monoclonal antibody therapy, mRNA vaccine, pandemic, SARS-CoV-2, Vaccine, viral, virology, virus, viruses
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.
TWiV 696: Tear down that SARS-CoV-2 manuscript
- December 20, 2020
- Tagged as: coronavirus, COVID-19, mRNA vaccine, pandemic, reverse transcriptase, SARS-CoV-2, viral, virology, virus, viruses
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.
TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin
- December 18, 2020
- Tagged as: clinical report, COVID-19, monoclonal antibody, mRNA vaccine, pandemic, SARS-CoV-2, steroid, vaccine allergy, viral, virology, virus, viruses
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.
Inside a BSL-4
