Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale’s SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Robert Fullilove
Links for this episode
- Health of racial and ethnic minority groups (CDC) 24:39
- COVID-19 death/hospitalization by race/ethnicity (CDC) 19:20
- Racial and ethnic disparities in workplace COVID-19 (CDC) 21:30
- College Behind Bars (PBS)
- SalivaDirect EUA (FDA) 1:10:54
- Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm) 1:18:27
- Letters read on TWiV 655 1:01:12, 1:17:12, 1:28:52
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to firstname.lastname@example.org
The download link is for the older TWiV 652 episode. The TWiV 655 file does exist where one expects it.
Would you please request to assist with blood warm-up on possible virus/parasite/poison for Alexander Nevalny, the Russian investigative journalist, please? Perhaps as an outreach to the doc in Russia or wherever he is today?
Mark Galeotti was interviewed at Euronews and that is my contact. Thank you.
So grateful to you all for TWIV – we are loyal listeners and have been for years.
On another note, perhaps while Novak Djokovic is in the NYC area, you could reach out and educate him!
““I see that the international media has taken that out of context a little bit, saying that I am completely against vaccines of any kind,” he said. “My issue here with vaccines is if someone is forcing me to put something in my body. That I don’t want. For me that’s unacceptable. I am not against vaccination of any kind, because who am I to speak about vaccines when there are people that have been in the field of medicine and saving lives around the world? I’m sure that there are vaccines that have little side effects that have helped people and helped stop the spread of some infections around the world.”
But Djokovic did express concern about potential issues with a coronavirus vaccine.
“How are we expecting that to solve our problem when this coronavirus is mutating regularly from what I understand?” he said.”
Preaching to the Choir
After 40 years it is strange that people go looking for the HIV virus and do everything they can to be infected. Glad HIV is not an air borne disease or we all would be in trouble.
With the COVID-19 it seems like the HIV virus we are all inform about this virus and know what can happen if infected. Everyone gets this disease and will spread it to everyone else. The young who are healthy feel a slight cold and will snap back, but are still contagious to others.
Maybe you need a Tee-Shirt that says “ I have COVID-19 since you are not mask can we share my virus”?
This virus is a good study for what Americans will do during a plague. When ISIL was in its powerful State I expected that they would have sent a batch of Ebola to the US and have spread it around.
This current virus is a study in Biology Warfare and what people will and not do to not get it a disease that can kill you. Even that they know about it will not masked.
Guess not enough of your neighbors are dying from it. Not enough of young people are dying from it.
Vincent and all: this was a superb episode with a compelling guest,..Thanks so much for giving Dr. Fullilove a platform to share his valuable insights and dare I say his optimism for humanity.
Re: TWIV 655, letters
First, the temperature is 69 degrees with 83% humidity in San Diego.
Background, I am an epidemiologist, although in neuroscience, but SARS-CoV-2 is a historical event. Hearing both Michael Mina and Ralph Baric are great, particularly, someone from UNC, where I earned by doctorate.
Regarding the question of sensitivityvs specificity. For every test that I know, sensitivityand specificity are inversely related. Thus, as sensitivity declines, the specificity should increase. Easy enough to demonstrate with a worked example using a neuropsychological test. I would expect the same here; so, lowering the sensitivity, at some increased risk of false negative but likely not infectious, the specificity should increase, with few to no, false positives.
I also was in the pharmaceutical industry for more than a couple of decade. The issue is if a clinical trial is designed with a specific statistical hypothesis, say 50% , then you either reject the hypothesis or not. Going back and saying I only saw 30%, you have no idea if that is really different from zero; as while you pre-specified the alpha error when the analysis is performed you have no idea of the beta error. To estimate the beta error, you need to know the true effect and you only have what you observed. This does not mean that the FDA would not allow use but it is an issue, one of many, of statistical inference.
IMPORTANT!! Yes I see that someone already posted about the incorrect link, but while I think Vincent does a great job organizing these web links, it is crucial to get this typo fixed ASAP because I really really want to recommend this particular episode but with the broken link I can’t, because some of my friends will just be confused.
Thanks for all you do, and don’t feel bad. I am merely anxious to post the link!!
This was incredibly thoughtful and informing. How on earth have I never heard of Robert Fullilove? This goes to show that all of the social contagion and change are not unrelated the biological contagion of SARS and other viruses.
I will check out this documentary – .. I’m not seeing the link in the show notes – but this appears to be available on PBS as well as Netflix…https://www.pbs.org/show/college-behind-bars/
Thanks as always,
First we have the biological pandemic, and then the social psychology pandemic: the West Denial Virus. I suppose you should have a political-economy specialist and a psychologist as guests sometime.
There is no such thing as a social psychology pandemic. Kucharski overreaches there… as did Ronald Ross.and and Hilda Hudson and many others before him… hopefully TWiV will come back to that… but there is great harm in analogizing models despite there power and beauty.
do a TWIRB – this week in race baiting
Wow! What a great episode. Dr. Fullilove was inspiring and informative. I can’t wait to share this with my pre-nursing students. I agree that it would be great to have him on again!
Please note the dose 200 mg vs high doses on trials. That’s why people died. Huge error. Alert Daniel
Love your podcasts.