This Week in Virology

TWiV 563: BLT on mice

September 1, 2019

The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Waning of influenza vaccine protection (Clin Inf Dis) 20:42
Precision mouse models for microbial pathogenesis (Nat Biotech) 33:55
Letters read on TWiV 563 9:50, 58:07
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:17:18

Brianne – Why we need to increase diversity in the immunology research community
Alan – Stock photos of vaccination that don’t suck
Kathy – Sample size calculator
Vincent – How Economics Shapes Science by Paula Stephan

Listener Picks

Melinda – Zome Tools

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 562: Take a breath

August 25, 2019

TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln

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Download TWiV 562 (77 MB .mp3, 127 min)
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Viruses of plant-interacting fungi (Adv Virus Res) 49:49
Why are RNA virus mutation rates so damn high? (PLoS Biol) 59:59
CRESS viruses (Adv Virus Res) 1:07:32
Coccolithovirus facilitation of carbon export in North Atlantic (Nat Micro) 1:18:04, 1:22:49
Silicon limitation facilitates virus infection of marine diatoms (Nat Micro) 1:40:22
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Download TWiV 561 (57 MB .mp3, 93 min)
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Links for this episode

Two new and effective Ebolavirus treatments (NIH, Nature) 3:16
A virus in a fungus in a plant (Science) 20:33
Dampened NLRP3-mediated inflammation in bats (Nat Micro) 32:55
Bat tolerance to virus infection (Nat Micro) 33:55
Image credit
Letters read on TWiV 561 1:07:27
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:18:03

Brianne – Deaf student makes sign language terms to communicate science
Alan – Show Your Stripes
Vincent – Sixty Years of Discovery

Listener Picks

Eric – This drug could end HIV – why hasn’t it?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 560: CEIRS, influenza and company

August 11, 2019

From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations.

Guests: Alan Embry, Florian Krammer, and Jennifer Nayak

Host: Vincent Racaniello

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Download TWiV 560 (37 MB .mp3, 61 min)
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Links for this episode

NIAID CEIRS 13:57
12th CEIRS meeting summary (pdf) 14:08
Antibody response to influenza virus (Nat Rev Micro) 46:01
Influenza virus CD4 T cells in children and young adults (Sci Rep) 53:58
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 559: Nectin connection what’s your infection?

August 4, 2019

The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,Kathy Spindler, and Brianne Barker

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Download TWiV 559 (65 MB .mp3, 108 min)
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Weekly Science Picks 1:29:13

Brianne – DukeMed Distinguished Award: Bill Joklik
Alan – Audubon photography awards for 2019
Rich – Joklik paper on vaccinia virus mRNA; Joklik MEM
Dickson – Ghost orchid pollination revealed
Kathy – Crocheted petri plates
Vincent – Documents relating to history of ASV

Listener Picks

Neva – What happens if we engineer a superbug?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 558: Joklik’s legacy

July 28, 2019

From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Sid Grossberg and Pat Spear

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Download TWiV 558 (37 MB .mp3, 61 min)
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Links for this episode

American Society for Virology 1:07
Bill Joklik, 92 5:17
How ASV was founded (Virology) 15:08
Signatures at the Chicago meeting (page one, page two) 28:01
Timeline history of ASV (jpg) 45:13
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 557: Congress in Rotterdam

July 21, 2019

From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic.

Hosts: Vincent Racaniello and Ben Berkhout

Guests: Ron Fouchier, Rosina Girones, and Marie-Paule Kieny

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Download TWiV 557 (41 MB .mp3, 67 min)
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Links for this episode

ECV2019 00:34
Drift of human H2N2 viruses (J Viral) 7:50
Viruses in urban sewage (Sci Tot Environ) 26:20
Ebola virus vaccine efficacy (Lancet) 52:46
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 556: Glycolyl’s not for the birds

July 14, 2019

TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Download TWiV 556 (62 MB .mp3, 103 min)
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Links for this episode

Deficits in children born to Zika virus infected mothers (Nat Med) 10:44
Zika virus is still a threat (NY Times) 33:49
N-glycolyl-neuraminic acid as influenza virus receptor (Cell Rep) 35:34
Letters read on TWiV 556 6:02, 1:06:54
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:27:27

Brianne – Foldable viral capsid models and Foldable models demonstrate T numbers
Alan – Laws Guide to Nature Drawing and Journaling
Dickson – NASA 50th Events
Kathy – Altas Obscura’s 17,069 strange and wonderful places
Vincent – TWiEVO 44: The enemy of my enemy is my phage

Listener Picks

Anthony – Global Water Pathogen Project

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 555: Fidelity and the single cell

July 7, 2019

From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology.

Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager

Guest: Craig Cameron

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Download TWiV 555 (46 MB .mp3, 76 min)
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Links for this episode

Cameron laboratory 1:52
Curioscity podcast 1:04:47
Ribavirin is an RNA virus mutagen (Nat Med) 13:19
RNA virus error catastrophe: test using ribavirin (PNAS) 18:08
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 554: Full fathom five thy viromes lie

June 30, 2019

A trio of TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole.

Hosts: Vincent Racaniello, Kathy Spindler, and Alan Dove

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Download TWiV 554 (48 MB .mp3, 79 min)
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Links for this episode

Australian Influenza Surveillance 19:24
Real-time tracking of influenza H3N2 18:46
ANP32B, or not to be (eLife) 26:19
ANP32B on TWiV 377 27:04
Species specific differences in ANP32B for influenza virus replication (eLife) 26:46, 33:42
Marine viral DNA diversity pole to pole (Cell) 38:00
Letters read on TWiV 554 8:30, 59:47
Timestamps by Jolene. Thanks!